Art

J-GLOBAL ID：200902212039207809   Reference number：09A0729905

A Pharmacokinetic and Dose Escalation Study of Pegfilgrastim (KRN125) in Lung Cancer Patients with Chemotherapy-induced Neutropenia

化学療法により誘発された好中球減少を呈する肺癌患者におけるpegfilgrastim(KRN125)の薬物動態および用量漸増研究

Author (7)： YAMAMOTO Nobuyuki (Shizuoka Cancer Center, Shizuoka) ,  SEKINE Ikuo (National Cancer Center Hospital) ,  NAKAGAWA Kazuhiko (Kinki Univ. School of Medicine) ,  TAKADA Minoru (Kinki-chuo Chest Medical Center, Osaka) ,  FUKUOKA Masahiro (Kinki Univ. School of Medicine) ,  TANIGAWARA Yusuke (Keio Univ. School of Medicine, Tokyo) ,  SAIJO Nagahiro (National Cancer Center Hospital East, Chiba, JPN)
Material： Japanese Journal of Clinical Oncology  (JJCO)
Volume： 39  Issue： 7  Page： 425-430  Publication year： Jul. 2009 
JST Material Number： W2222A  ISSN： 0368-2811  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： *ペグフィルグラスチム

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JST classification (3)： Drug therapy(=pharmacotherapy)for tumors  (GE03032C) ,  Tumors(=neoplasms)of respiratory system  (GI04000G) ,  Treatment for poisning  (GD06030M)

Reference (10)：

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• Delgado C, Francis GE, Fisher D. The uses and properties of PEG-linked proteins. Crit Rev Ther Drug Carrier Syst 1992; 9: 249-304.
• Johnston E, Crawford J, Blackwell S, Bjurstrom T, Lockbaum P, Roskos L, et al. Randomized, dose-escalation study of SD/01 compared with daily filgrastim in patients receiving chemotherapy. J Clin Oncol 2000; 18: 2522-28.
• Balms FA, Johnes SE, O’Shaughnessy J, Vukelja S. George T, Savin M, et al. Comparable efficacy and safety profiles of once-per-cycle pegfilgrastim and daily injection filgrastim in chemotherapy-induced neutropenia: a multicenter dose-finding study in women with breast cancer. Ann Onco12002; 13: 903-9.
• Holms FA, O’Shaughnessy J, Vukelja S, Jones SE, Shogan J, Savin M, et al. Blinded randomized, multicenter study to evaluate single administration pegfilgrastim once per cycle versus daily filgrastim as an adjunct to chemotherapy in patients with high-risk stage II or stage III/IV breast cancer. J Clin Oncol 2002; 20: 727-31.

Terms in the title (9)： 化学療法 ,  誘発 ,  好中球減少 ,  肺癌 ,  患者 ,  薬物動態 ,  用量 ,  漸増 ,  研究