Art

J-GLOBAL ID：200902213092799900   Reference number：05A0602735

Effect of Protein Binding of Pilsicainide on the Pharmacokinetics

ピルシカイニドの薬物動態に及ぼす蛋白質結合の影響

Author (8)： FUKUMOTO Kyoko (Niigata Univ. Pharmacy and Applied Life Sci.) ,  TANEMURA Mamiko (Niigata Univ. Pharmacy and Applied Life Sci.) ,  TSUCHISHITA Yoshimasa (Maizuru Kyosai Hospital) ,  KUSUMOTO Masaaki (Maizuru Kyosai Hospital) ,  MATSUMOTO Kana (Niigata Univ. Pharmacy and Applied Life Sci.) ,  MATSUMOTO Kana (Kyoritsu hospital) ,  KAMAKURA Shiro (National Cardiovascular Center) ,  UENO Kazuyuki (Niigata Univ. Pharmacy and Applied Life Sci.)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 20  Issue： 3  Page： 183-186  Publication year： Jun. 27, 2005 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *antiarrhythmic drug ,...
Semi thesaurus term： alpha 1 acid glycoprotein

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JST classification (2)： Basic biopharmacy  (GY01021U) ,  Basic research of cardioactive drugs  (GW07020N)

Substance index (1)： Pilzicainide

Reference (7)：

• 1) Hattori, Y., Hidaka, T., Aisaka, K., Satoh, F. and Ishihara, T.: Effect of SUN 1165, a new antiarrhythmic agent, on the kinetics of rate-dependent block of Na channels and ventricular conduction of extrasystoles. J. Cardiovasc. Pharmacol., 11: 407-412 (1988).
• 2) Hayashi, T., Kanai, Y., Takauchi, Y., Takehisa, M., Sugita, O. and Ohnuma, N.: Studies on metabolism and disposition of a new antiarrhythmic agent, SUN1165 (I)-absorption and excretion of SUN1165 in rats [in Japanese]. Clin. Rep., 23: 17-29 (1989).
• 3) Takabatake, E., Isobe, M., Natsuki, R., Sone, T. and Matsuo, R.: Studies on metabolism and disposition of a new antiarrhythmic agent, SUN1165 (V)-metabolism and disposition of SUN1165 in dogs [in Japanese]. Clin. Rep., 23: 85-97 (1989).
• 4) Hayashi, T., Takehisa, M., Sugita, O. and Oonuma, N.: Studies on metabolism and disposition of a new antiarrhythmic agent, SUN1165 (VI)-absorption and disposition of SUN1165 in monkey [in Japanese]. Clin. Rep., 23: 99-105 (1989).
• 5) Oda, S., Tsukazaki, T., Kuroo, M. and Kuramoto, K.: Pharmacokinetics and pharmacodynamics of SUN1165 in geriatric patients [in Japanese]. Geriat. Med., 27: 1033-1044 (1989).

Terms in the title (3)： ピルシカイニド ,  薬物動態 ,  蛋白質結合