Art

J-GLOBAL ID：200902213416471938   Reference number：04A0046471

Negamycin Restores Dystrophin Expression in Skeletal and Cardiac Muscles of mdx Mice

ネガマイシンはmdxマウスの骨格筋及び心筋におけるジストロフィン発現を回復する

Author (9)： ARAKAWA M (Univ. Tokyo, Tokyo) ,  SHIOZUKA M (Univ. Tokyo, Tokyo) ,  NAKAYAMA Y (Tokyo Metropolitan Inst. of Medical Sci., Tokyo) ,  HARA T (Tokyo Metropolitan Inst. of Medical Sci., Tokyo) ,  HAMADA M (Inst. of Microbial Chemistry, Tokyo) ,  KONDO S (Inst. of Microbial Chemistry, Tokyo) ,  SHEYKHOLESLAMI K (Univ. Tokyo, Tokyo) ,  KITAMURA T (Univ. Tokyo, Tokyo) ,  SUZUKI-MIYAGOE Y (National Inst. of Neurosci., Tokyo)
Material： Journal of Biochemistry  (J Biochem)
Volume： 134  Issue： 5  Page： 751-758  Publication year： Nov. 01, 2003 
JST Material Number： F0286A  ISSN： 0021-924X  CODEN： JOBIAO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *muscular dystrophy ,...
Semi thesaurus term： gentamicin ,...

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JST classification (2)： Pharmacology of antibiotics in general  (GX05010R) ,  Basic neurology  (GN01020W)

Reference (40)：

• WILHELM, J. M. Aminoglycoside antibiotics and eukaryotic protein synthesis : stimulation of errors in the translation of natural messengers in extracts of cultured human cells. Biochemistry. 1978, 17, 1149-1153
• BURKE, J. F. Suppression of a nonsense mutation in mammalian cells in vivo by the aminoglycoside antibiotics G-418 and paromomycin. Nucleic Acids Res. 1985, 13, 6265-6272
• HOWARD, M. T. Aminoglycoside antibiotics restore CFTR function by overcoming premature stop mutations. Nat. Med. 1996, 2, 467-469
• BEDWELL, D. M. Suppression of a CFTR premature stop mutation in a bronchial epithelial cell line. Nat. Med. 1997, 3, 1280-1284
• CLANCY, J. P. Evidence that systemic gentamicin suppresses premature stop mutations in patients with cystic fibrosis. Amer. J. Respir. Crit. Care Med. 2001, 163, 1683-1692

Terms in the title (7)： ネガマイシン ,  MDXマウス ,  骨格筋 ,  心筋 ,  ジストロフィン ,  発現 ,  回復