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J-GLOBAL ID：200902213535657896   Reference number：04A0038057

Effect of Amlodipine and Cilazapril Treatment on Platelet Ca²⁺ Handling in Spontaneously Hypertensive Rats

高血圧自然発症ラットにおける血小板Ca²⁺代謝に対するアムロジピンおよびシラザプリル投与の影響

Author (9)： OSHIMA T (Hiroshima Univ. Graduate School of Biomedical Sci., Hiroshima, JPN) ,  ONO N (Hiroshima Univ. Graduate School of Biomedical Sci., Hiroshima, JPN) ,  OZONO R (Hiroshima Univ. Graduate School of Biomedical Sci., Hiroshima, JPN) ,  HIGASHI Y (Hiroshima Univ. Graduate School of Biomedical Sci., Hiroshima, JPN) ,  ISHIDA M (Hiroshima Univ. Graduate School of Biomedical Sci., Hiroshima, JPN) ,  ISHIDA T (Hiroshima Univ. Graduate School of Biomedical Sci., Hiroshima, JPN) ,  MIHO N (Hiroshima Univ. Graduate School of Biomedical Sci., Hiroshima, JPN) ,  NAKASHIMA H (Hiroshima Univ. Graduate School of Biomedical Sci., Hiroshima, JPN) ,  YANO Y (Hiroshima Univ. Graduate School of Biomedical Sci., Hiroshima, JPN)
Material： Hypertension Research  (Hypertens Res)
Volume： 26  Issue： 11  Page： 901-906  Publication year： Nov. 2003 
JST Material Number： Y0303A  ISSN： 0916-9636  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *essential hypertension ,...
Semi thesaurus term： calcium channel blocker ,...

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JST classification (2)： Basic medicine on cardiovascular system  (GJ01020K) ,  Basic research of vasoactive drugs and hypotensive drugs  (GW07040J)

Substance index (4)： Amlodipine ,  Cilazapril ,  Ionomycin ,  Fura-2

Reference (29)：

• 1. Erne P, Bolli P, Bürg Isser E, Bühler FR: Correlation of platelet calcium with blood pressure: effect of antihypertensive therapy. N Engl J Med 1984; 310: 1084-1088.
• 2. Oshima T, Matsuura H, Matsumoto K, et al: Role of intracellular free calcium in the hypotensive response to nifedipine, in Omae T, Zanchetti A (eds): How Should Elderly Hypertensive Patients Be Treated? Tokyo, Springer-Verlag, 1989, pp 151-155.
• 3. Hiraga H, Oshima T, Yoshimura M, Matsuura H, Kajiyama G: Abnormal platelet Ca²⁺ handling accompanied by increased cytosolic free Mg²⁺ in essential hypertension. Am J Physiol 1998; 275: R574-R579.
• 4. Asano M, Nomura Y: Calcium buffering of resting, voltage-dependent Ca²⁺ influx by sarcoplasmic reticulum in femoral arteries from spontaneously hypertensive rats at prehypertensive stage. Hypertens Res 2001; 24: 271-282.
• 5. Nomura Y, Asano M: Increased Ca²⁺ buffering function of sarcoplasmic reticulum in small mesenteric arteries from spontaneously hypertensive rats. Hypertens Res 2002; 25: 231-239.

Terms in the title (6)： 高血圧自然発症ラット ,  血小板 ,  代謝 ,  アムロジピン ,  シラザプリル ,  投与