Art

J-GLOBAL ID：200902214362127930   Reference number：07A0903655

Therapy with Bortezomib plus Dexamethasone Induces Osteoblast Activation in Responsive Patients with Multiple Myeloma

ボルテゾミブ+デキサメタゾンによる治療は多発性骨髄腫反応性の患者に骨芽細胞活性化を誘導する

Author (24)： OZAKI Shuji (Univ. Tokushima Graduate School of Health Biosciences, Tokushima, JPN) ,  OZAKI Shuji (Tokushima Univ. Hospital, Tokushima, JPN) ,  TANAKA Osamu (Univ. Tokushima Graduate School of Health Biosciences, Tokushima, JPN) ,  TANAKA Osamu (Tokushima Univ. Hospital, Tokushima, JPN) ,  FUJII Shiro (Univ. Tokushima Graduate School of Health Biosciences, Tokushima, JPN) ,  FUJII Shiro (Tokushima Univ. Hospital, Tokushima, JPN) ,  SHIGEKIYO Yuri (Univ. Tokushima Graduate School of Health Biosciences, Tokushima, JPN) ,  MIKI Hirokazu (Univ. Tokushima Graduate School of Health Biosciences, Tokushima, JPN) ,  MIKI Hirokazu (Tokushima Univ. Hospital, Tokushima, JPN) ,  CHORAKU Masahito (Univ. Tokushima Graduate School of Health Biosciences, Tokushima, JPN) ,  CHORAKU Masahito (Tokushima Univ. Hospital, Tokushima, JPN) ,  KAGAWA Kumiko (Univ. Tokushima Graduate School of Health Biosciences, Tokushima, JPN) ,  KAGAWA Kumiko (Tokushima Univ. Hospital, Tokushima, JPN) ,  ASANO Jin (Univ. Tokushima Graduate School of Health Biosciences, Tokushima, JPN) ,  ASANO Jin (Tokushima Univ. Hospital, Tokushima, JPN) ,  TAKEUCHI Kyoko (Univ. Tokushima Graduate School of Health Biosciences, Tokushima, JPN) ,  TAKEUCHI Kyoko (Tokushima Univ. Hospital, Tokushima, JPN) ,  KITAZOE Ken-ichi (Univ. Tokushima Graduate School of Health Biosciences, Tokushima, JPN) ,  KITAZOE Ken-ichi (Tokushima Univ. Hospital, Tokushima, JPN) ,  HASHIMOTO Toshihiro (Univ. Tokushima Graduate School of Health Biosciences, Tokushima, JPN) ,  HASHIMOTO Toshihiro (Tokushima Univ. Hospital, Tokushima, JPN) ,  ABE Masahiro (Univ. Tokushima Graduate School of Health Biosciences, Tokushima, JPN) ,  ABE Masahiro (Tokushima Univ. Hospital, Tokushima, JPN) ,  MATSUMOTO Toshio (Univ. Tokushima Graduate School of Health Biosciences, Tokushima, JPN)
Material： International Journal of Hematology  (Int J Hematol)
Volume： 86  Issue： 2  Page： 180-185  Publication year： Aug. 15, 2007 
JST Material Number： F0888A  ISSN： 0925-5710  CODEN： IJHEEY  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *Multiple Myeloma ,...
Semi thesaurus term： *bortezomib ,...

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JST classification (4)： Blood cell tumors(=neoplasms)  (GK04000M) ,  Drug therapy(=pharmacotherapy)for tumors  (GE03032C) ,  Clinical application of antitumor(=antineoplastic)drugs  (GW16020L) ,  Hormones,cytokines,bioactive peptides in general  (EB08010W)

Substance index (1)： Dexamethasone

Reference (34)：

• KYLE, RA. Multiple myeloma. N Engl J Med. 2004, 351, 1860-1873
• ROODMAN, GD. Pathogenesis of myeloma bone disease. Blood Cells Mol Dis. 2004, 32, 290-292
• BARLOGIE, B. Treatment of multiple myeloma. Blood. 2004, 103, 20-32
• MITSIADES, CS. The role of the bone microenvironment in the pathophysiology and therapeutic management of multiple myeloma : interplay of growth factors, their receptors and stromal interactions. Eur J Cancer. 2006, 42, 1564-1573
• ABE, M. Osteoclasts enhance myeloma cell growth and survival via cell-cell contact : a vicious cycle between bone destruction and myeloma expansion. Blood. 2004, 104, 2484-2491

Terms in the title (9)： ボルテゾミブ ,  デキサメタゾン ,  治療 ,  多発性骨髄腫 ,  反応性 ,  患者 ,  骨芽細胞 ,  活性化 ,  誘導