Art

J-GLOBAL ID：200902216188675586   Reference number：05A0650556

Stereoselective Synthesis of Premisakinolide A, the Monomeric Counterpart of the Marine 40-Membered Dimeric Macrolide Misakinolide A

海産40員二量体性マクロライド,ミサキノリドAの単量体性対応物,プレミサキノリドAの立体選択的合成

Author (3)： NAKAMURA Ryoichi (Hokkaido Univ., Sapporo, JPN) ,  TANINO Keiji (Hokkaido Univ., Sapporo, JPN) ,  MIYASHITA Masaaki (Hokkaido Univ., Sapporo, JPN)
Material： Organic Letters  (Org Lett)
Volume： 7  Issue： 14  Page： 2929-2932  Publication year： Jul. 07, 2005 
JST Material Number： W1171A  ISSN： 1523-7060  CODEN： ORLEF7  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *cyclic ether ,...
Semi thesaurus term： Aldol condensation

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JST classification (1)： Dioxanes,oxathians,dithians  (CF07099G)

Substance index (17)： Misakinolide A ,  Premisakinolide A ,  (2S)-2α-[(2S,3S)-2-Methoxy-3-methyl-4-hydroxypentyl]-6β-allyl-3,6-dihydro-2H-pyran ,  (2S)-2α-[(2S,3S)-2-Methoxy-3-methyl-4-hydroxypentyl]-6β-(4-oxo-2-butenyl)-3,6-dihydro-2H-pyran ,  (2S)-2α-[(2S,3S)-2-Methoxy-3-methyl-4-hydroxypentyl]-6β-[(2R)-3β-(hydroxymethyl)glycidyl]-3,6-dihydro-2H-pyran ,  (2S)-2α-[(2S,3R)-2-Methoxy-3-methyl-4-oxopentyl]-6β-[(2R)-2-hydroxy-4-oxobutyl]-3,6-dihydro-2H-pyran ,  (5S)-2-Methyl-5-(tert-butyldimethylsiloxy)-6-[(2R)-6β-[(2S,3R)-2-methoxy-3-methyl-4-oxopentyl]-5,6-dihydro-2H-pyran-2α-yl]-2-hexenoic acid methyl ester ,  (S)-3-Hydroxybutyric acid methyl ,  (2R)-2α-Acetoxy-4α-methoxy-6α-methyltetrahydro-2H-pyran ,  Pivalic acid (2S,3S,4S,5S,6S)-2,4,6-trimethyl-3-hydroxy-5-(triethylsiloxy)-7-(benzyloxy)heptyl ester ,  (2S,3S,4S,5S,6S)-2,4,6-Trimethyl-3,5-(di-tert-butylsilanediylbisoxy)-7-(benzyloxy)-1-heptanol ,  (3S,4S,5S,6S,7S)-3,5,7-Trimethyl-4,6-(di-tert-butylsilanediylbisoxy)-8-(benzyloxy)-1-octyne ,  (4S)-2,2-Di-tert-butyl-4β-[(S)-1-methyl-2-(benzyloxy)ethyl]-5β-methyl-6α-[(1S)-1-methyl-3-[(2R)-4α-methoxy-6α-methyltetrahydro-2H-pyran-2β-yl]-2-propynyl]-1,3-dioxa-2-silacyclohexane ,  (2S,3S,4S)-2-[(2R)-2-(4-Methoxyphenyl)-5β-methyl-1,3-dioxane-4α-yl]-4-methyl-6-[(2S)-4α-methoxy-6α-methyltetrahydro-2H-pyran-2β-yl]-3-hexanol ,  (2R,3R,4R,5S,6S)-2,4,6-Trimethyl-3-(4-methoxybenzyloxy)-5-(methoxymethoxy)-8-[(2S)-4α-methoxy-6α-methyltetrahydro-2H-pyran-2β-yl]octanal ,  (5S)-2-Methyl-5-(tert-butyldimethylsiloxy)-6-[(2R)-6β-[(2S,3R)-2-methoxy-3-methyl-4-(trimethylsiloxy)-4-pentenyl]-5,6-dihydro-2H-pyran-2α-yl]-2-hexenoic acid methyl ester ,  (5S)-2-Methyl-5-(tert-butyldimethylsiloxy)-6-[(2R)-6β-[(2S,3R,6R,7S,8S,9R,10S,11S)-2-methoxy-3,7,9,11-tetramethyl-4-oxo-6-hydroxy-8-(4-methoxybenzyloxy)-10-(methoxymethoxy)-13-[(2S)-4α-methoxy-6α-methyltetrahydro-2H-pyran-2β-yl]tridecyl]-5,6-dihydro-2H-pyran-2α-yl]-2-hexenoic acid methyl ester

Terms in the title (5)： 二量体 ,  マクロライド ,  ミサキノリドA ,  単量体 ,  立体選択的合成