Engineering the Substrate Specificity of Porcine Kidney D-Amino Acid Oxidase by Mutagenesis of the “Active-Site Lid”

SETOYAMA Chiaki; NISHINA Yasuzo; MIZUTANI Hisashi; MIYAHARA Ikuko; HIROTSU Ken; KAMIYA Nobuo; SHIGA Kiyoshi; MIURA Retsu

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J-GLOBAL ID：200902216623349866 Reference number：06A0536778

Engineering the Substrate Specificity of Porcine Kidney D-Amino Acid Oxidase by Mutagenesis of the “Active-Site Lid”

ブタ腎臓のD-アミノ酸オキシダーゼの「活性部位リッド(ふた)」の変異誘発による基質特異性のエンジニアリング

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Volume： 139 Issue： 5 Page： 873-879 Publication year： May. 01, 2006
JST Material Number： F0286A ISSN： 0021-924X CODEN： JOBIAO Document type： Article
Article type：原著論文 Country of issue： Japan (JPN) Language： ENGLISH (EN)

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Enzyme in general , Animal biochemistry

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Reference (15)：

CURTI, B. D- and L-Amino acid oxidases. Chemistry and Biochemistry of Flavoenzymes. 1992, 3, 69-94
PILONE, M. S. D-Amino acid oxidase : new findings. Cell. Mol. Life Sci. 2000, 57, 1732-1747
NEGRI, A. The primary structure of the flavoprotein D-aspartate oxidase from beef kidney. J. Biol. Chem. 1992, 267, 11865-11871
MIZUTANI, H. Three-dimensional structure of porcine kidney D-amino acid oxidase at 3.0 A resolution. J. Biochem. 1996, 120, 14-17
MATTEVI, A. Crystal structure of D-amino acid oxidase : A case of active site mirror-image convergent evolution with flavocytochrome b_2. Proc. Natl Acad. Sci. USA. 1996, 93, 7496-7501

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