Art

J-GLOBAL ID：200902217533900357   Reference number：07A0040501

GENE EXPRESSION PROFILE IN LIVER OF DIFFERING AGES OF RATS AFTER SINGLE ORAL ADMINISTRATION OF ACETAMINOPHEN

アセトアミノフェンの単回経口投与後の異なる年齢のラットの肝臓における遺伝子発現プロファイル

Author (10)： MORISHITA Katsumi (Toxicogenomics Project, National Inst. of Biomedical Innovation) ,  MIZUKAWA Yumiko (Dep. of Pathophysiology, Fac. of Pharmaceutical Sciences, Doshisha Women’s Coll. of Liberal Arts) ,  KASAHARA Toshihiko (Toxicogenomics Project, National Inst. of Biomedical Innovation) ,  OKUYAMA Manabu (Toxicogenomics Project, National Inst. of Biomedical Innovation) ,  TAKASHIMA Kayoko (Toxicogenomics Project, National Inst. of Biomedical Innovation) ,  TORITSUKA Naoki (Toxicogenomics Project, National Inst. of Biomedical Innovation) ,  MIYAGISHIMA Toshikazu (Toxicogenomics Project, National Inst. of Biomedical Innovation) ,  NAGAO Taku (National Institiute of Health Sciences) ,  URUSHIDANI Tetsuro (Toxicogenomics Project, National Inst. of Biomedical Innovation) ,  URUSHIDANI Tetsuro (Dep. of Pathophysiology, Fac. of Pharmaceutical Sciences, Doshisha Women’s Coll. of Liberal Arts)
Material： Journal of Toxicological Sciences  (J Toxicol Sci)
Volume： 31  Issue： 5  Page： 491-507 (J-STAGE)  Publication year： 2006 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： antipyretic analgesic ,...

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JST classification (3)： Toxicology in general  (GZ01000K) ,  Gene expression  (EC02040Q) ,  Basic medicine on digestive system  (GH01020E)

Substance index (4)： Acetaminophen ,  Isoniazide ,  Carbon Tetrachloride ,  Glutathione

Reference (25)：

• Allameh, A., Vansoun, E.Y. and Zarghi, A. (1997): Role of glutathione conjugation in protection of weanling rat liver acetaminophen-induced hepatotoxicity. Mech. Ageing. Dev., 95, 71-79.
• Bessems, J.G.M. and Vermeulen, N.P.E. (2001): Paracetamol (acetaminophen)-induced toxicity: Molecular and biochemical mechanisms, analogues and protective approaches. Crit. Rev. Toxicol., 31, 55-138.
• Buetler, T.M. and Eaton, D.L. (1992): Complementary DNA cloning, messsenger RNA expression, and induction of alpha-class glutathione S-transferases in mouse tissues. Cancer Res., 52, 314-318.
• Cohen, S.D. and Khairallah, E.A. (1997): Acetaminophen. In (Sipes, I.G., McQween, C.A. and Gandolfi, A.J., eds.), Comprehensive Toxicology, 9, Pergamon, Elsevier Science Inc. pp.329-343.
• Green, M.D., Shires, T.K. and Fischer, L.J. (1984): Hepatotoxicity of acetaminophen in neonatal and young rats. I. Age-related changes in susceptibility. Toxicol. Appl. Pharmacol., 74, 116-124.

Terms in the title (6)： アセトアミノフェン ,  経口投与 ,  年齢 ,  ラット ,  肝臓 ,  遺伝子発現プロファイル