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J-GLOBAL ID：200902217816413100   Reference number：09A0235754

Nicorandil Attenuates FeCl₃-Induced Thrombus Formation Through the Inhibition of Reactive Oxygen Species Production

ニコランジルは反応性酸素分子種生産阻害を介しFeCl₃誘導血栓形成を抑制する

Author (7)： EGUCHI Yu (Dep. of Physiology, Tokai Univ. School of Medicine) ,  TAKAHARI Youko (Teaching and Res. Support Center, Tokai Univ. School of Medicine) ,  HIGASHIJIMA Naoko (Dep. of Physiology, Tokai Univ. School of Medicine) ,  ISHIZUKA Nobuhiko (Fuji Gotemba Res. Laboratories, Chugai Pharmaceutical Co Ltd) ,  TAMURA Noriko (Dep. of Internal Medicine, Tokai Univ. School of Medicine) ,  KAWAMURA Yota (Dep. of Internal Medicine, Tokai Univ. School of Medicine) ,  ISHIDA Hideyuki (Dep. of Physiology, Tokai Univ. School of Medicine)
Material： Circulation Journal  (Circ J)
Volume： 73  Issue： 3  Page： 554-561 (J-STAGE)  Publication year： 2009 
JST Material Number： F0908A  ISSN： 1346-9843  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： vasodilator ,...
Semi thesaurus term： Arterial thrombosis ,...

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JST classification (1)： Basic medicine on cardiovascular system  (GJ01020K)

Substance index (5)： Nicorandil ,  Tirofiban ,  Diazoxide ,  Isosorbide dinitrate ,  L-NAME

Reference (33)：

• 1. Cai H. Hydrogen peroxide regulation of endothelial function: Origins, mechanisms, and consequences. Cardiovasc Res 2005; 68: 26-36.
• 2. Heistad DD. Oxidative stress and vascular disease [2005 Duff lecture]. Arterioscler Thromb Vasc Biol 2006; 26: 689-695.
• 3. Sekiya M, Sato M, Funada J, Ohtani T, Akutsu H, Watanabe K. Effects of the long-term administration of nicorandil on vascular endothelial function and the progression of arteriosclerosis. J Cardiovasc Pharmacol 2005; 46: 63-67.
• 4. Ishibashi Y, Takahashi N, Tokumaru A, Karino K, Sugamori T, Sakane T, et al. Effects of long-term nicorandil administration on endothelial function, inflammation, and oxidative stress in patients without coronary artery disease. J Cardiovasc Pharmacol 2008; 51: 311-316.
• 5. O'Rourke B. Myocardial KATP channels in preconditioning. Circ Res 2000; 87: 845-855.

Terms in the title (6)： ニコランジル ,  反応性酸素分子種 ,  阻害 ,  FeCl3 ,  誘導 ,  血栓形成