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J-GLOBAL ID：200902219563528846   Reference number：05A0005602

Selective Endothelin ET_B Receptor Antagonist Improves Left Ventricular Function but Exaggerates Degeneration of Cardiomyocytes in J2N-k Hamsters

選択的エンドセリンET_B受容体アンタゴニストはJ2N-kハムスターにおいて,左心室機能を改善するが,心筋細胞の変性を悪化させる

Author (9)： NISHIDA M (Osaka Univ. Pharmaceutical Sci., Osasa, JPN) ,  HAYASHI T (Osaka Medical Coll., Osasa, JPN) ,  IESHIMA M (Osaka Univ. Pharmaceutical Sci., Osasa, JPN) ,  ESHIRO K (Osaka Univ. Pharmaceutical Sci., Osasa, JPN) ,  YOSHIYAMA M (Osaka City Univ. Medical School, Osasa, JPN) ,  YOSHIKAWA J (Osaka City Univ. Medical School, Osasa, JPN) ,  MORI T (Osaka Medical Coll., Osasa, JPN) ,  OKADA Y (Osaka Medical Coll., Osasa, JPN) ,  KITAURA Y (Osaka Medical Coll., Osasa, JPN)
Material： Circulation Journal  (Circ J)
Volume： 69  Issue： 1  Page： 107-113  Publication year： Jan. 2005 
JST Material Number： F0908A  ISSN： 1346-9843  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： hamster ,...
Semi thesaurus term： NADH oxidoreductase ,...

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JST classification (2)： Basic research of cardioactive drugs  (GW07020N) ,  Basic medicine on cardiovascular system  (GJ01020K)

Substance index (2)： Atrasentan ,  A-192621

Reference (41)：

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• 2. Rodeheffer RJ, Lerman A, Heublein DM, Burnett JC Jr. Increased plasma concentration of endothelin in congestive heart failure in humans. Mayo Clin Proc 1992; 67: 719-724.
• 3. Ito H, Hirata Y, Hiroe M, Tsujino M, Adachi S, Takamoto T, et al. Endothelin-1 induces hypertrophy with enhanced expression of muscle-specific genes in cultured neonatal rat cardiomyocytes. Circ Res 1991; 69: 209-215.
• 4. Ishikawa T, Yanagisawa M, Kimura S, Goto K, Masaki T. Positive inotropic action of novel vasoconstrictor peptide endothelin on guinea pig atria. Am J Physiol 1988; 225: H970-H973.
• 5. Ishikawa T, Yanagisawa M, Kimura S, Goto K, Masaki T. Positive chronotropic effects of endothelin, a novel endothelium-derived vasoconstrictor peptide. Pflugers Arch 1988; 413: 108-110.

Terms in the title (8)： エンドセリン ,  ETB受容体 ,  アンタゴニスト ,  ハムスター ,  左心室機能 ,  心筋細胞 ,  変性 ,  悪化