Art

J-GLOBAL ID：200902219862493455   Reference number：04A0208088

Biotransformation of Cystothiazole A, a Myxobacterial Antibiotic, into Novel Derivatives by the Mother Producer, Cystobacter fuscus

元の生産者Cystobacter fuscusによる粘液細菌抗生物質シストチアゾールAの新規誘導体へのバイオ転換

Author (3)： SUZUKI Y (Nagoya Univ., Nagoya, JPN) ,  OJIKA M (Nagoya Univ., Nagoya, JPN) ,  SAKAGAMI Y (Nagoya Univ., Nagoya, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 68  Issue： 2  Page： 390-396  Publication year： Feb. 23, 2004 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Bacteria ,...
Semi thesaurus term： Cystobacter fuscus

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JST classification (1)： Antibiotic fermentation  (GX03000S)

Substance index (9)： Cystothiazole A ,  Cystothiazole B ,  Cystothiazole C ,  Cystothiazole D ,  Melithiazole B ,  (2E,4R,5S,6E)-3-Methoxy-4-methyl-5-hydroxy-7-[2′-(1-hydroxy-1-methylethyl)-2,4′-bithiazole-4-yl]-2,6-heptadienoic acid methyl ester ,  (2E,4R,5S,6E)-3-Methoxy-4-methyl-5-hydroxy-7-[2′-(1,2-dihydroxy-1-methylethyl)-2,4′-bithiazole-4-yl]-2,6-heptadienoic acid methyl ester ,  (2E,4R,5S,6E)-3-Methoxy-4-methyl-5-hydroxy-7-[2′-[(R)-1,2-dihydroxy-1-methylethyl]-2,4′-bithiazole-4-yl]-2,6-heptadienoic acid methyl ester ,  (2E,4R,5S,6E)-3-Methoxy-4-methyl-5-hydroxy-7-[2′-[(S)-1,2-dihydroxy-1-methylethyl]-2,4′-bithiazole-4-yl]-2,6-heptadienoic acid methyl ester

Reference (10)：

• 1) Bollag, D. M., McQuency, P. A., Zhu, J., Hensens, O., Koupal, L., Liesch, J., Goetz, E., Lazarides, E., and Woods, C. M., Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res., 55, 2325–2333 (1995).
• 2) Gerth, K., Bedorf, N., Höfle, G., Irschik, H., and Reichenbach, H., Epothilones A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (myxobacteria). Production, physico-chemical and biological properties. J. Antibiot., 49, 560–563 (1996).
• 3) Reichenbach, H., and Höfle, G., Production of bioactive secondary metabolites. In “Myxobacteria II”, eds. Dworkin, M., and Kaiser, D., American Society for Microbiology, Washington, pp. 347–397 (1993).
• 4) Reichenbach, H., and Höfle, G., Myxobacteria as producers of secondary metabolites. In “Drug Discovery from Nature”, eds. Grabley, S., and Thiericke, R., Springer, Berlin, pp. 149–179 (1999).
• 5) Ojika, M., Suzuki, Y., Tsukamoto, A., Sakagami, Y., Fudou, R., Yoshimura, T., and Yamanaka, S., Cystothiazole A and B, new bithiazole-type antibiotics from the myxobacterium Cystobacter fuscus. J. Antibiot., 51, 275–281 (1998).

Terms in the title (5)： 粘液細菌 ,  抗生物質 ,  シストチアゾールA ,  誘導体 ,  転換