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J-GLOBAL ID：200902220414868691   Reference number：03A0788666

Embryonic Lethal Effect of Expressing a Dominant Negative Mutant Human Thyroid Hormone Receptor α1 in Mice

マウスにおける優性負の変異体ヒト甲状腺ホルモン受容体α1の胎児致死効果

Author (8)： NISHIYAMA K (Hamamatsu Univ. School of Medicine, Sizuoka, JPN) ,  BABA S (Hamamatsu Univ. School of Medicine, Sizuoka, JPN) ,  YAMADA T (Hamamatsu Univ. School of Medicine, Sizuoka, JPN) ,  MATSUSHITA A (Hamamatsu Univ. School of Medicine, Sizuoka, JPN) ,  NATSUME H (Hamamatsu Univ. School of Medicine, Sizuoka, JPN) ,  NAKANO K (Hamamatsu Univ. School of Medicine, Sizuoka, JPN) ,  SASAKI S (Hamamatsu Univ. School of Medicine, Sizuoka, JPN) ,  NAKAMURA H (Hamamatsu Univ. School of Medicine, Sizuoka, JPN)
Material： Endocrine Journal  (Endocr J)
Volume： 50  Issue： 5  Page： 561-570  Publication year： Oct. 2003 
JST Material Number： F0625A  ISSN： 0918-8959  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： mouse(animal) ,...
Semi thesaurus term： 甲状腺ホルモン受容体アルファ1 ,...

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JST classification (3)： Development(=generation)and differentiation  (EJ16020W) ,  Structure and chemistry of genes  (EC02020U) ,  Receptors on cell membrane  (EF04030C)

Reference (29)：

• 1. Forrest D, Sjöberg M, Vennström B (1990) Contrasting developmental and tissue-specific expression of alpha and beta thyroid hormone receptor genes. EMBO J 9: 1519-1528.
• 2. Strait KA, Schwartz HL, Perez-Castillo A, Oppenheimer JH (1990) Relationship of T3R mRNA content to tissue triiodothyronine nuclear binding capacity and function in developing and adult rats. J Biol Chem 265: 10514-10521.
• 3. Abel ED, Boers ME, Pazos-Moura C, Moura E, Kaulbach H, Zakaria M, Lowell B, Radovick S, Liberman MC, Wondisford F (1999) Divergent roles for thyroid hormone receptor β isoforms in the endocrine axis and auditory system. J Clin Invest 104: 291-300.
• 4. Forrest D, Erway LC, Ng L, Altschuler R, Curran T (1996) Thyroid hormone receptor beta is essential for development of auditory function. Nature Gene 13: 354-357.
• 5. Ribeiro MO, Carvalho SD, Schultz JJ, Chiellini G, Scanlan TS, Bianco AC, Brent GA (2001) Thyroid hormone-sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform-specific. J Clin Invest 108: 97-105.

Terms in the title (6)： マウス ,  変異体 ,  ヒト ,  甲状腺ホルモン受容体α ,  胎児 ,  致死効果