Art

J-GLOBAL ID：200902221075772309   Reference number：05A0169821

A Novel Model of Obesity-Related Diabetes: Introgression of the Lepr^fa Allele of the Zucker Fatty Rat into Nonobese Spontaneously Diabetic Torii (SDT) Rats

肥満性糖尿病の新しいモデル:Zucker fattyラットのレプチン受容体遺伝子fa変異の非肥満性糖尿病モデルSpontaneously Diabetic Torii(SDT)ラットへの移入

Author (3)： MASUYAMA T (JAPAN TOBACCO Inc., Kanagawa) ,  KATSUDA Y (Torii Pharmaceutical Co. Ltd., Tokyo, JPN) ,  SHINOHARA M (Torii Pharmaceutical Co. Ltd., Tokyo, JPN)
Material： Experimental Animals  (実験動物ニュース)
Volume： 54  Issue： 1  Page： 13-20  Publication year： Jan. 2005 
JST Material Number： Z0755A  ISSN： 1341-1357  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： obesity ,...
Semi thesaurus term： insulin resistance ,...

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JST classification (2)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Laboratry organisms  (EA03070Y)

Reference (23)：

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• 3. Chung, W.K., Zheng, M., Chua, M., Kershaw, E., Power-Kehoe, L., Tsuji, M., Wu-Peng, X.S., Williams, J., Chua, S.C. Jr., and Leibel, R.L. 1997. Genetic modifiers of Lepr^fa associated with variability in insulin production and susceptibility to NIDDM. Genomics 41: 332-344.
• 4. Guberski, D.L., Butler, L., Manzi, S.M., Stubbs, M., and Like, A.A. 1993. The BBZ/Wor rat: clinical characteristics of the diabetic syndrome. Diabetologia 36: 912-919.
• 5. Ikeda, H., Shino, A., Matsuo, T., Iwatsuka, H., and Suzuoki, Z. 1981. A new genetically obese-hyperglycemic rat (Wistar Fatty). Diabetes 30: 1045-1050.

Terms in the title (6)： 肥満性糖尿病 ,  モデル ,  ラット ,  レプチン受容体遺伝子 ,  FA ,  変異