Art

J-GLOBAL ID：200902221764812806   Reference number：05A0821758

Voglibose potentiates the hepatotoxicity of carbon tetrachloride and acetaminophen by inducing CYP2E1 in rats

ボグリボースはラットにおいてCYP2E1の誘導により四塩化炭素とアセトアミノフェンの肝毒性を増強する

Author (6)： QIN Li-qiang (Dep. of Obstetrics and Gynecology, School of Medicine, Univ. of Yamanashi, Shimokato 1110, Tamaho Town, Yamanashi ...) ,  WANG Pei-yu (Dep. of Social Medicine & Health Education, School of Public Health, Peking Univ., Xueyuan Road 38, Haidian District ...) ,  WANG Yuan (Internal Medicine, Fourth Affiliated Hospital, Hebei Medical Univ., Jiankang Road 12, Shijiazhuang, Hebei Province ...) ,  KANEKO Takashi (Dep. of Environmental Health, School of Medicine, Univ. of Yamanashi, Shimokato 1110, Tamaho Town, Yamanashi ...) ,  HOSHI Kazuhiko (Dep. of Obstetrics and Gynecology, School of Medicine, Univ. of Yamanashi, Shimokato 1110, Tamaho Town, Yamanashi ...) ,  SATO Akio (Dep. of Environmental Health, School of Medicine, Univ. of Yamanashi, Shimokato 1110, Tamaho Town, Yamanashi ...)
Material： Hepatology Research  (Hepatol Res)
Volume： 33  Issue： 1  Page： 50-56  Publication year： Sep. 2005 
JST Material Number： W1284A  ISSN： 1386-6346  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： rat ,...
Semi thesaurus term： *dyshepatia ,...

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JST classification (1)： Basic medicine on digestive system  (GH01020E)

Substance index (4)： Voglibose ,  Carbon Tetrachloride ,  Acetaminophen ,  Malondialdehyde

Reference (44)：

• HORII, S. Synthesis and α-D-glucosidase inhibitory activity of N-substituted valiolamine derivatives as potent oral antidiabetic agents. J Med Chem. 1987, 29, 1038-1046
• GOKE, B. Voglibose (AO-128) is an efficient α-glucosidase inhibitor and mobilizes the endogenous GLP-1 reserve. Digestion. 1995, 56, 493-501
• ODAKA, H. Effect of a disacchridese inhibitor, AO-128, on post-prandial hyperglycemia in rats. J Jpn Soc Nutr Food Sci. 1992, 45, 27-31
• MATSUO, T. Effect of an intestinal disacchridase inhibitor (AO-128) on obexity and diabetes. Am J Clin Nutr. 1992, 55, 314S-317S
• KLEIST, P. Voglibose has no effect on the pharmacokinetics of hydrochlorothiazide. Eur J Clin Pharmacol. 1998, 54, 273-274

Terms in the title (8)： ボグリボース ,  ラット ,  CYP2E1 ,  誘導 ,  四塩化炭素 ,  アセトアミノフェン ,  肝毒性 ,  増強