Art

J-GLOBAL ID：200902222332294843   Reference number：07A1216742

Additive Mutagenic Effects of DNA Damages Induced by Multiple Mutagens at Virtually Non-mutagenic Dose Level of Each

実質的に各々では非変異原性用量レベルでの複数の変異原により誘導されるDNA損傷の相加的変異誘発効果

Author (1)： OHTA Toshihiro (School of Life Sciences, Tokyo Univ. of Pharmacy and Life Sciences)
Material： Genes and Environment  (Genes Environ)
Volume： 29  Issue： 4  Page： 141-145 (J-STAGE)  Publication year： 2007 
JST Material Number： X0839A  ISSN： 1880-7046  CODEN： GEENGP  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： mutagen ,...

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JST classification (1)： Genetic variation  (EC01030Y)

Substance index (4)： AF-2 ,  4-Nitroquinoline-1-oxide ,  1-Nitropyrene ,  Captan

Reference (23)：

• KIRSCH-VOLDERS, M. Concepts of threshold in mutagenesis and carcinogenesis. Mutat Res. 2000, 464, 3-11
• SEILER, JP. Apparent and real threshold : a study on two mutagens. Progress in Genetic Toxicology. 1977, 233-238
• SOFUNI, T. Genotoxicity : Is a threshold concept applicable to evaluate the mutagenic activity of DNA-targeting substances?. Environ Mutagen Res. 2005, 27, 61-73
• SOFUNI, T. Semi-quantitative evaluation of genotoxic activity of chemical substances and evidence for a biological threshold of genotoxic activity. Mutat Res. 2000, 464, 97-104
• JENKINS, GJS. Do dose response thresholds exist for genotoxic alkylating agents?. Mutagenesis. 2005, 20, 389-398

Terms in the title (6)： 変異原性 ,  用量 ,  変異原 ,  誘導 ,  DNA損傷 ,  変異誘発