Art

J-GLOBAL ID：200902222398954216   Reference number：07A0628807

High glucose concentrations impair the activation of K⁺ channels and proteases in undifferentiated THP-1 monocytes

高濃度のグルコースが未分化THP-1単球のK⁺チャネル及びプロテアーゼの活性を損なう

Author (5)： ASAOKA Hiroshi (Tokyo Medical and Dental Univ.) ,  ASAOKA Hiroshi (International Univ. Health and Welfare) ,  KUROKAWA Junko (Tokyo Medical and Dental Univ.) ,  FURUKAWA Tetsushi (Tokyo Medical and Dental Univ.) ,  SHIMOKADO Kentaro (Tokyo Medical and Dental Univ.)
Material： Journal of Medical and Dental Sciences  (J Med Dent Sci)
Volume： 54  Issue： 1  Page： 97-102  Publication year： Mar. 2007 
JST Material Number： F0606A  ISSN： 1342-8810  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： cathepsin ,...
Semi thesaurus term： cathepsin G ,...

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JST classification (3)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Biophylaxis and immune systems in general  (ED01010F) ,  Hormones,cytokines,bioactive peptides in general  (EB08010W)

Substance index (1)： Glucose

Reference (18)：

• 1. Gallacher SJ, Thomson G, Fraser WD, et al. Neutrophil bactericidal function in diabetes mellitus: evidence for association with blood glucose control. Diabet Med 1995;12:916-920.
• 2. Kjersem H, Hilsted J, Madsbad S, et al. Polymorphonuclear leucocyte dysfunction during short term metabolic changes from norm-to hyperglycemia in type 1 (insulin dependent) diabetic patients. Infection 1988;16:215-221.
• 3. Nelson CP, Hindson DA. Inhibition of polymorphnuclear leukocyte respiratory burst by elevated glucose concentrations in vitro. Diabetes 1989;38:1031-1035.
• 4. McManus L, Bloodworth R, Prihoda T, et al. Agonist-dependent failure of neutrophil function in diabetes correlates with extent of hyperglycemia. J Leukocyte Biol 2001;70:395-404.
• 5. Graves DT, Naguib G, Lu H, et al. Inflammation is more persistent in Type 1 Diabetic Mice. J Dent Res 2005;84:324-328.

Terms in the title (7)： 高濃度 ,  グルコース ,  分化 ,  単球 ,  K+チャネル ,  プロテアーゼ ,  活性