Art

J-GLOBAL ID：200902222743863474   Reference number：09A0833833

Prognostic significance of the immunohistochemical expression of O⁶-methylguanine-DNA methyltransferase, P-glycoprotein, and multidrug resistance protein-1 in glioblastomas

グリア芽腫におけるO⁶-メチルグアニン-DNAメチルトランスフェラーゼ,P-糖蛋白質と多剤耐性蛋白質-1の免疫組織学的発現の予測的意義

Author (6)： NAKAGAWA Takao (Univ. Fukui, JPN) ,  IDO Kazunori (Univ. Fukui, JPN) ,  SAKUMA Takahiro (Univ. Fukui, JPN) ,  TAKEUCHI Hiroaki (Univ. Fukui, JPN) ,  SATO Kazufumi (Univ. Fukui, JPN) ,  KUBOTA Toshihiko (Univ. Fukui, JPN)
Material： Neuropathology
Volume： 29  Issue： 4  Page： 379-388  Publication year： Aug. 2009 
JST Material Number： W0751A  ISSN： 0919-6544  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： *multidrug resistance protein 1 ,...

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JST classification (2)： Tumors(=neoplasms)of nervous system  (GN04000V) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Reference (18)：

• MINEO, JF. Prognosis factors of survival time in patients with glioblastoma multiforme : a multivariate analysis of 340 patients. Acta Neurochir (Wien). 2007, 149, 245-253
• BELANICH, M. Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine. Cancer Res. 1996, 56, 783-788
• ANDA, T. Relationship between expression of O6-methylguanine-DNA methyltransferase, glutathione-S-transferase pi in glioblastoma and the survival of the patients treated with nimustine hydrochloride : an immunohistochemical analysis. Neurol Res. 2003, 25, 241-248
• HEGI, ME. Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide. Clin Cancer Res. 2004, 10, 1871-1874
• BLANC, JL. Correlation of clinical features and methylation status of MGMT gene promoter in glioblastomas. J Neurooncol. 2004, 68, 275-283

Terms in the title (7)： グリア芽腫 ,  メチルグアニン ,  P-糖蛋白質 ,  多剤耐性蛋白質 ,  免疫組織学 ,  発現 ,  予測