Art

J-GLOBAL ID：200902223784771009   Reference number：08A0887506

Spinocerebellar ataxia type 6 knockin mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant Ca_V2.1 channels

脊髄小脳失調症6型ノックインマウスは変異Ca_v2.1チャンネルの年齢依存的蓄積に伴って進行性神経機能障害を進展する

Author (15)： WATASE Kei (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  WATASE Kei (Baylor Coll. of Medicine, TX) ,  BARRETT Curtis F. (Stanford Univ. School of Medicine, CA) ,  MIYAZAKI Taisuke (Hokkaido Univ. School of Medicine, Sapporo, JPN) ,  ISHIGURO Taro (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  ISHIKAWA Kinya (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  HU Yuanxin (Univ. Chicago, IL) ,  UNNO Toshinori (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  SUN Yaling (Baylor Coll. of Medicine, TX) ,  KASAI Sayumi (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  WATANABE Masahiko (Hokkaido Univ. School of Medicine, Sapporo, JPN) ,  GOMEZ Christopher M. (Univ. Chicago, IL) ,  MIZUSAWA Hidehiro (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  TSIEN Richard W. (Stanford Univ. School of Medicine, CA) ,  ZOGHBI Huda Y. (Baylor Coll. of Medicine, TX)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 105  Issue： 33  Page： 11987-11992  Publication year： Aug. 19, 2008 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *Calcium Channels ,  spinocerebellar degeneration ,  congenital disease ,  Mus musculus ,  laboratory animal ,  Amino Acid Sequence ,  repetitive sequence ,  dependence ,  Alternative Splicing ,  ion current ,  Purkinje Cells ,  experimental disease ,  Cell Fractionation ,  animal test ,  motor function test ,  molecular genetic phenomenon ,  *Cerebellum ,  nucleotide sequence ,  knock-in mouse ,  polyglutamine stretch ,  voltage dependency ,  voltage dependent calcium channel ,  laser microdissection ,  Rotarod Performance Test ,  protein expression ,  *Ion Transport ,  *transportation ,  *Biological Transport ,  *transmembrane protein ,  *ion transport(in vivo) ,  Myomorpha ,  *Brain
Semi thesaurus term： *Ca_v2.1チャンネル ,  脊髄小脳失調症6型

JST classification (2)： Transport of cell membrane  (EF04020R) ,  Central nervous system  (EJ12030F)

Terms in the title (9)： 脊髄小脳失調症6型 ,  ノックインマウス ,  変異 ,  チャンネル ,  年齢 ,  蓄積 ,  神経 ,  機能障害 ,  進展