Art
J-GLOBAL ID：200902223784771009   Reference number：08A0887506

Spinocerebellar ataxia type 6 knockin mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant CaV2.1 channels

脊髄小脳失調症6型ノックインマウスは変異Cav2.1チャンネルの年齢依存的蓄積に伴って進行性神経機能障害を進展する
Author (15)：
WATASE Kei

About WATASE Kei

(Tokyo Medical and Dental Univ., Tokyo, JPN)

About Tokyo Medical and Dental Univ., Tokyo, JPN

, 
WATASE Kei

About WATASE Kei

(Baylor Coll. of Medicine, TX)

About Baylor Coll. of Medicine, TX

, 
BARRETT Curtis F.

About BARRETT Curtis F.

(Stanford Univ. School of Medicine, CA)

About Stanford Univ. School of Medicine, CA

, 
MIYAZAKI Taisuke

About MIYAZAKI Taisuke

(Hokkaido Univ. School of Medicine, Sapporo, JPN)

About Hokkaido Univ. School of Medicine, Sapporo, JPN

, 
ISHIGURO Taro

About ISHIGURO Taro

(Tokyo Medical and Dental Univ., Tokyo, JPN)

About Tokyo Medical and Dental Univ., Tokyo, JPN

, 
ISHIKAWA Kinya

About ISHIKAWA Kinya

(Tokyo Medical and Dental Univ., Tokyo, JPN)

About Tokyo Medical and Dental Univ., Tokyo, JPN

, 
HU Yuanxin

About HU Yuanxin

(Univ. Chicago, IL)

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, 
UNNO Toshinori

About UNNO Toshinori

(Tokyo Medical and Dental Univ., Tokyo, JPN)

About Tokyo Medical and Dental Univ., Tokyo, JPN

, 
SUN Yaling

About SUN Yaling

(Baylor Coll. of Medicine, TX)

About Baylor Coll. of Medicine, TX

, 
KASAI Sayumi

About KASAI Sayumi

(Tokyo Medical and Dental Univ., Tokyo, JPN)

About Tokyo Medical and Dental Univ., Tokyo, JPN

, 
WATANABE Masahiko

About WATANABE Masahiko

(Hokkaido Univ. School of Medicine, Sapporo, JPN)

About Hokkaido Univ. School of Medicine, Sapporo, JPN

, 
GOMEZ Christopher M.

About GOMEZ Christopher M.

(Univ. Chicago, IL)

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, 
MIZUSAWA Hidehiro

About MIZUSAWA Hidehiro

(Tokyo Medical and Dental Univ., Tokyo, JPN)

About Tokyo Medical and Dental Univ., Tokyo, JPN

, 
TSIEN Richard W.

About TSIEN Richard W.

(Stanford Univ. School of Medicine, CA)

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, 
ZOGHBI Huda Y.

About ZOGHBI Huda Y.

(Baylor Coll. of Medicine, TX)

About Baylor Coll. of Medicine, TX


Material：
Proceedings of the National Academy of Sciences of the United States of America  (PNAS)

About Proceedings of the National Academy of Sciences of the United States of America


Volume： 105  Issue： 33  Page： 11987-11992  Publication year： Aug. 19, 2008 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)
Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
*calcium channel

About calcium channel

, 
spinocerebellar degeneration

About spinocerebellar degeneration

, 
congenital disease

About congenital disease

, 
mouse(animal)

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, 
laboratory animal

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, 
amino acid sequence

About amino acid sequence

, 
repetitive sequence

About repetitive sequence

, 
dependence

About dependence

, 
alternative splicing

About alternative splicing

, 
ion current

About ion current

, 
Purkinje cell

About Purkinje cell

, 
experimental disease

About experimental disease

, 
cell fractionation

About cell fractionation

, 
animal test

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, 
motor function test

About motor function test

, 
molecular genetic phenomenon

About molecular genetic phenomenon

, 
*cerebellum

About cerebellum

, 
nucleotide sequence

About nucleotide sequence


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
*Cav2.1チャンネル

About Cav2.1チャンネル

, 
knock-in mouse

About knock-in mouse

, 
polyglutamine stretch

About polyglutamine stretch

, 
脊髄小脳失調症6型

About 脊髄小脳失調症6型

, 
voltage dependency

About voltage dependency

, 
voltage-gated calcium channel

About voltage-gated calcium channel

, 
laser microdissection

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, 
Rotarod Performance Test

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, 
protein expression

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JST classification (2)：
JST classification
Category name(code) classified by JST.
Transport of cell membrane 
(EF04020R)

About Transport of cell membrane

,  Central nervous system 
(EJ12030F)

About Central nervous system

Terms in the title (9)：
Terms in the title
Keywords automatically extracted from the title.
脊髄小脳失調症6型

About 脊髄小脳失調症6型

, 
ノックインマウス

About ノックインマウス

, 
変異

About 変異

, 
チャンネル

About チャンネル

, 
年齢

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, 
蓄積

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, 
神経

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, 
機能障害

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, 
進展

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