Art

J-GLOBAL ID：200902225124448070   Reference number：09A1032217

Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance

一次肝細胞代謝,機能的分極,遺伝子発現および薬剤クリアランスの酸素仲介増強

Author (7)： KIDAMBI Srivatsan (Harvard Medical School, MA) ,  YARMUSH Rubin S. (Harvard Medical School, MA) ,  NOVIK Eric (HμREL Corp., CA) ,  CHAO Piyun (HμREL Corp., CA) ,  YARMUSH Martin L. (Harvard Medical School, MA) ,  NAHMIAS Yaakov (Harvard Medical School, MA) ,  NAHMIAS Yaakov (Hebrew Univ. Jerusalem, Jerusalem, ISL)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 106  Issue： 37  Page： 15714-15719  Publication year： Sep. 15, 2009 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *hepatocyte ,  vascular endothelial cell ,  hepatic toxicity ,  drug metabolism ,  human ,  Rattus ,  cytochrome P450 ,  gene expression ,  Environment ,  culture (biology) ,  hyperoxia ,  coculture ,  clearance ,  cultured cell ,  fibroblast ,  drug interaction ,  nitrogen heterocyclic compound ,  aromatic fluorine compound ,  aromatic chlorine compound ,  polynuclear aromatic compound ,  alicyclic compound ,  spiro-compound ,  acid imide ,  ether ,  fatty acid ,  macrocyclic compound ,  hydrazone ,  lactam ,  oxygen heterocyclic compound ,  polyphenol ,  bridged compound ,  carboxylate (ester) ,  hydroxy ketone ,  polyol ,  steroid ,  lactone ,  oligosaccharide ,  glycoside (except carbohydrate) ,  deoxysugar ,  pyranoside ,  microenvironment ,  3T3-J2 cell ,  Genetic Profile ,  Myomorpha ,  molecular genetic phenomenon ,  alicyclic alcohol ,  diol ,  sulfur heterocyclic compound ,  aminoalcohol ,  secondary amine ,  secondary alcohol ,  aromatic ketone ,  aromatic compound ,  urea compound ,  sulfoxide ,  phenol ether
Semi thesaurus term： gene expression profile ,  Hyperoxidation ,  cultivation process

JST classification (2)： Liver  (EJ06060J) ,  Cell and tissue culture methods  (EA03040R)

Substance index (11)： Midazolam ,  Buspirone ,  Rifampin ,  Digoxin ,  Timolol ,  Naringenin ,  Antipyrine ,  Carbamazepine ,  Omeprazole ,  Metoprolol ,  Sildenafil

Terms in the title (9)： 肝細胞 ,  代謝 ,  分極 ,  遺伝子発現 ,  薬剤 ,  クリアランス ,  酸素 ,  仲介 ,  増強