Art

J-GLOBAL ID：200902225812926377   Reference number：09A0427446

Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies

in vitroでTDP43のC末断片を発現するとTDP43蛋白質異常症の病的特徴が再現される

Author (9)： IGAZ Lionel M. (Univ. Pennsylvania School of Medicine, Pennsylvania) ,  KWONG Linda K. (Univ. Pennsylvania School of Medicine, Pennsylvania) ,  CHEN-PLOTKIN Alice (Univ. Pennsylvania School of Medicine, Pennsylvania) ,  WINTON Matthew J. (Univ. Pennsylvania School of Medicine, Pennsylvania) ,  UNGER Travis L. (Univ. Pennsylvania School of Medicine, Pennsylvania) ,  XU Yan (Univ. Pennsylvania School of Medicine, Pennsylvania) ,  NEUMANN Manuela (Univ. Hospital of Zuerich, Zuerich, CHE) ,  TROJANOWSKI John Q. (Univ. Pennsylvania School of Medicine, Pennsylvania) ,  LEE Virginia M.-Y. (Univ. Pennsylvania School of Medicine, Pennsylvania)
Material： Journal of Biological Chemistry  (J Biol Chem)
Volume： 284  Issue： 13  Page： 8516-8524  Publication year： Mar. 27, 2009 
JST Material Number： E0038A  ISSN： 0021-9258  CODEN： JBCHA3  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *DNA binding protein ,  *Amyotrophic Lateral Sclerosis ,  Ubiquitination ,  aggregation ,  RNA splicing ,  *Dementia ,  brain disease ,  phosphorylation ,  Brain ,  Amino Acid Sequence ,  proteolysis ,  human ,  tumor cell ,  cultured cell ,  COS cell ,  HEK293 cell ,  RNA interference ,  *TDP-43 ,  neuro 2A cell ,  COS-7 cell ,  molecular genetic phenomenon ,  Heredity
Semi thesaurus term： *FTLD

JST classification (2)： Basic neurology  (GN01020W) ,  Biological function  (EB03040U)

Terms in the title (4)： TDP43 ,  断片 ,  発現 ,  TDP43蛋白質