Art

J-GLOBAL ID：200902227289340455   Reference number：09A0645298

Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria

パルミチン酸はH4IIEC3肝細胞においてミトコンドリアで生産される活性酸素種によりインシュリン耐性を誘導する

Author (12)： NAKAMURA Seiji (Kanazawa Univ. Graduate School of Medical Sci.) ,  TAKAMURA Toshinari (Kanazawa Univ. Graduate School of Medical Sci.) ,  MATSUZAWA-NAGATA Naoto (Kanazawa Univ. Hospital, Kanazawa, JPN) ,  TAKAYAMA Hiroaki (Kanazawa Univ. Graduate School of Medical Sci.) ,  MISU Hirofumi (Kanazawa Univ. Graduate School of Medical Sci.) ,  NODA Hiroyo (Kanazawa Univ. Graduate School of Medical Sci.) ,  NABEMOTO Satoko (Kanazawa Univ. Graduate School of Medical Sci.) ,  KURITA Seiichiro (Kanazawa Univ. Graduate School of Medical Sci.) ,  OTA Tsuguhito (Kanazawa Univ. Graduate School of Medical Sci.) ,  ANDO Hitoshi (Kanazawa Univ. Graduate School of Medical Sci.) ,  MIYAMOTO Ken-ichi (Kanazawa Univ. Hospital, Kanazawa, JPN) ,  KANEKO Shuichi (Kanazawa Univ. Graduate School of Medical Sci.)
Material： Journal of Biological Chemistry  (J Biol Chem)
Volume： 284  Issue： 22  Page： 14809-14818  Publication year： May. 29, 2009 
JST Material Number： E0038A  ISSN： 0021-9258  CODEN： JBCHA3  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： cultured cell ,  hepatocyte ,  Rattus ,  Proteins ,  JNK MAP kinase ,  Mitochondria ,  *active oxygen ,  carnitine O-palmitoyltransferase ,  serine-threonine kinase ,  electron transport system ,  phosphorylation ,  beta-oxidation ,  *fatty acid ,  aliphatic amine ,  thiol ,  carboxamide ,  sulfur containing amino acid ,  oxygen heterocyclic compound ,  aromatic chlorine compound ,  carboxylate (salt) ,  phenol ether ,  nitrile ,  hydrazone ,  organofluorine compound ,  organosulphur compound ,  sulfur heterocyclic compound ,  diketone ,  ketone ,  olefin compound ,  polynuclear aromatic compound ,  insulin ,  *Insulin resistance ,  carnitine palmitoyltransferase I ,  tyrosine phosphorylation ,  saturated fatty acid ,  insulin receptor substrate-2 ,  Electron Transport Chain Complex Proteins ,  Myomorpha ,  hypoglycemic drug ,  metabolic drug ,  carbohydrate metabolic drug ,  drug
Semi thesaurus term： insulin ,  *insulin resistance ,  Akt ,  H4IIEC3細胞 ,  IRS-2 ,  respiratory chain complex

JST classification (4)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Pancreatic hormones  (EB08020H) ,  Cell physiology in general  (EF02010S) ,  Basic research of drugs acting on carbohydrate metabolism  (GW13020Q)

Substance index (7)： Acetylcysteine ,  SP-600125 ,  Etomoxir ,  Carbonyl Cyanide m-Chlorophenyl Hydrazone ,  Thenoyltrifluoroacetone ,  Palmitic Acid ,  Rotenone

Terms in the title (6)： パルミチン酸 ,  肝細胞 ,  ミトコンドリア ,  活性酸素種 ,  インシュリン耐性 ,  誘導