Art

J-GLOBAL ID：200902228090945672   Reference number：04A0360017

Novel Lipoxygenase Inhibitors, Tetrapetalone B, C, and D from Streptomyces sp.

Streptomyces sp.由来の新規なリポキシゲナーゼ阻害剤,テトラペタロンB,C,およびD

Author (5)： KOMODA T (Univ. Shizuoka, Shizuoka, JPN) ,  KISHI M (Univ. Shizuoka, Shizuoka, JPN) ,  ABE N (Univ. Shizuoka, Shizuoka, JPN) ,  SUGIYAMA Y (Univ. Shizuoka, Shizuoka, JPN) ,  HIROTA A (Univ. Shizuoka, Shizuoka, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 68  Issue： 4  Page： 903-908  Publication year： Apr. 23, 2004 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： lipoxygenase ,...
Semi thesaurus term： Streptomyces

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JST classification (1)： Enzyme in general  (EB09010D)

Substance index (4)： Tetrapetalone A ,  Tetrapetalone B ,  Tetrapetalone C ,  Tetrapetalone D

Reference (7)：

• 1) Samuelsson, B., Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science, 220, 568–575 (1983).
• 2) Ghosh, J., and Myers, C. E., Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer calls. Proc. Natl. Acad. Sci. U.S.A., 95, 13182–13187 (1998).
• 3) Bell, R. L., Young, P. R., Albert, D., Lanni, C., Summers, J. B., Brooks, D. W., Rubin, P., and Carter, G. W. I., The discovery and development of zileuton: an orally active 5-lipoxygenase inhibitor. Int. J. Immunopharmacol., 14, 505–510 (1992).
• 4) Komoda, T., Morimitsu, Y., Hirota, H., and Hirota, A., USF-19A, a new lipoxygenase inhibitor from Streptomyces sp. Biosci. Biotechnol. Biochem., 59, 924–926 (1995).
• 5) Komoda, T., Sugiyama, Y., Abe, N., Imachi, M., Hirota, H., and Hirota, A., Tetrapetalone A, a novel lipoxygenase inhibitor from Streptomyces sp. Tetrahedron Lett., 44, 1659–1661 (2003).

Terms in the title (3)： Streptomyces ,  リポキシゲナーゼ阻害剤 ,  テトラペタロンB