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J-GLOBAL ID：200902229003373532   Reference number：04A0177559

Repeated Treatment With the Traditional Medicine Unsei-in Inhibits Substance P-Induced Itch-Associated Responses Through Downregulation of the Expression of Nitric Oxide Synthase 1 in Mice

マウスにおける伝統的薬物温清飲の反復処置は一酸化窒素シンターゼ発現のダウンレギュレーションを介してサブスタンスP誘発性かゆみ関連反応を阻害する

Author (5)： ANDOH T (Toyama Medical and Pharmaceutical Univ., Toyama, JPN) ,  AL-AKEEL A (Toyama Medical and Pharmaceutical Univ., Toyama, JPN) ,  TSUJII K (Toyama Medical and Pharmaceutical Univ., Toyama, JPN) ,  NOJIMA H (Toyama Medical and Pharmaceutical Univ., Toyama, JPN) ,  KURAISHI Y (Toyama Medical and Pharmaceutical Univ., Toyama, JPN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 94  Issue： 2  Page： 207-210  Publication year： Feb. 01, 2004 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Chinese drug ,...
Semi thesaurus term： 一酸化窒素シンターゼ1

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JST classification (1)： Basic research of pharmacology of crude drugs  (GX06020J)

Substance index (1)： 7-Nitroindazole

Reference (15)：

• 1 Andoh T, Honma Y, Kawaharada S, Al-Akeel A, Nojima H, Kuraishi Y. Inhibitory effect of the repeated treatment with Unsei-in on substance P-induced itch-associated responses through the downregulation of the expression of NK₁ tachykinin receptor in mice. Biol Pharm Bull. 2003;26:896–898.
• 2 Mousli M, Bronner C, Landry Y, Bockaert J, Rouot B. Direct activation of GTP-binding regulatory proteins (G-proteins) by substance P and compound 48/80. FEBS Lett. 1990;259:260–262.
• 3 Kuraishi Y, Nagasawa T, Hayashi K, Satoh M. Scratching behavior induced by pruritogenic but not algesiogenic agents in mice. Eur J Pharmacol. 1995;275:229–233.
• 4 Andoh T, Nagasawa T, Satoh M, Kuraishi Y. Substance P induction of itch-associated response mediated by cutaneous NK₁ tachykinin receptors in mice. J Pharmacol Exp Ther. 1998;286:1140–1145.
• 5 Andoh T, Kuraishi Y. Inhibitory effects of azelastine on substance P-induced itch-associated response in mice. Eur J Pharmacol. 2002;436:235–239.

Terms in the title (11)： マウス ,  薬物 ,  温清飲 ,  反復 ,  処置 ,  一酸化窒素シンターゼ ,  発現 ,  ダウンレギュレーション ,  サブスタンスP ,  かゆみ ,  阻害