Art

J-GLOBAL ID：200902229196354009   Reference number：08A0278396

A novel route for the construction of Taxol ABC-ring framework: skeletal rearrangement approach to AB-ring and intramolecular aldol approach to C-ring

タキソールのABC環骨格の新構築法 骨格転位によるAB環及び分子内アルドール反応によるC環の構築

Author (9)： ENOMOTO Terumichi (Graduate School of Materials Sci., Nara Inst. of Sci. and Technol. (NAIST), Takayama, Ikoma, Nara 630-0192, JPN) ,  MORIMOTO Tsumoru (Graduate School of Materials Sci., Nara Inst. of Sci. and Technol. (NAIST), Takayama, Ikoma, Nara 630-0192, JPN) ,  UENO Mifuyu (Graduate School of Materials Sci., Nara Inst. of Sci. and Technol. (NAIST), Takayama, Ikoma, Nara 630-0192, JPN) ,  MATSUKUBO Takanori (Graduate School of Materials Sci., Nara Inst. of Sci. and Technol. (NAIST), Takayama, Ikoma, Nara 630-0192, JPN) ,  SHIMADA Yumi (Graduate School of Materials Sci., Nara Inst. of Sci. and Technol. (NAIST), Takayama, Ikoma, Nara 630-0192, JPN) ,  TSUTSUMI Ken (Graduate School of Materials Sci., Nara Inst. of Sci. and Technol. (NAIST), Takayama, Ikoma, Nara 630-0192, JPN) ,  SHIRAI Ryuichi (Graduate School of Materials Sci., Nara Inst. of Sci. and Technol. (NAIST), Takayama, Ikoma, Nara 630-0192, JPN) ,  SHIRAI Ryuichi (Fac. of Pharmaceutical Sciences, Doshisha Women’s Coll. of Liberal Arts, Kodo, Kyotanabe, Kyoto 610-0395, JPN) ,  KAKIUCHI Kiyomi (Graduate School of Materials Sci., Nara Inst. of Sci. and Technol. (NAIST), Takayama, Ikoma, Nara 630-0192, JPN)
Material： Tetrahedron  (Tetrahedron Symposia-in-Print)
Volume： 64  Issue： 18  Page： 4051-4059  Publication year： Apr. 28, 2008 
JST Material Number： E0234A  ISSN： 0040-4020  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *alicyclic ketone ,  *bridged compound ,  chemical synthesis ,  rearrangement reaction ,  *aldol reaction ,  annulation ,  crystal structure ,  optimization ,  density functional method ,  alicyclic compound ,  fatty acid ,  aromatic carboxylic acid ,  oxygen heterocyclic compound ,  olefin compound ,  carboxylate(ester) ,  aminoalcohol ,  aminocarboxylic acid ,  secondary alcohol ,  hydroxy acid ,  hydroxy ketone ,  polyol

JST classification (1)： Bridged tri-or more-cyclic carbocyclic compounds  (CF06110B)

Substance index (10)： LDA (reagent) ,  Paclitaxel ,  8-Methylene-11,11-dimethyltricyclo[5.3.1.0^2,6]undecane-2,6-diol ,  8,11,11-Trimethylbicyclo[5.3.1]undeca-7-ene-2,6-dione ,  6-Oxo-8,11,11-trimethylbicyclo[5.3.1]undeca-7-ene-2-one ethylene acetal ,  8,11,11-Trimethylspiro[bicyclo[5.3.1]undeca-7-ene-2,2′-[1,3]dioxolane]-5β,6β-diol ,  (6S)-5-Oxo-6β-(triisopropylsiloxy)-8,11,11-trimethylbicyclo[5.3.1]undeca-7-ene-2-one ethylene acetal ,  (4R)-4β-(Methoxycarbonyl)-5-oxo-6β-(triisopropylsiloxy)-8,11,11-trimethylbicyclo[5.3.1]undeca-7-ene-2-one ethylene acetal ,  (4S)-4β-(4-Oxobutyl)-4-(methoxycarbonyl)-5-oxo-6β-(triisopropylsiloxy)-8,11,11-trimethylbicyclo[5.3.1]undeca-7-ene-2-one ,  (1ξ)-2,9-Dioxo-4-hydroxy-10α-(triisopropylsiloxy)-20-nortaxa-11-ene-19-oic acid methyl ester

Terms in the title (8)： タキソール ,  ABC ,  骨格 ,  構築 ,  転位 ,  環 ,  アルドール反応 ,  C環