Art

J-GLOBAL ID：200902229210219250   Reference number：04A0122976

Tetrapetalone A, a Novel Lipoxygense Inhibitor from Streptomyces sp.

Streptomyces sp.由来の新規なリポキシゲナーゼ阻害剤のテトラペタロンA

Author (8)： KOMODA T (Univ. Shizuoka, Shizuoka, JPN) ,  YOSHIDA K (Univ. Shizuoka, Shizuoka, JPN) ,  ABE N (Univ. Shizuoka, Shizuoka, JPN) ,  SUGIYAMA Y (Univ. Shizuoka, Shizuoka, JPN) ,  IMACHI M (Bruker BioSpin K. K., Tsukuba, JPN) ,  HIROTA H (RIKEN Genomics Sci. Center, Yokohama, JPN) ,  KOSHINO H (RIKEN, Saitama, JPN) ,  HIROTA A (Univ. Shizuoka, Shizuoka, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 68  Issue： 1  Page： 104-111  Publication year： Jan. 23, 2004 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： lipoxygenase ,...
Semi thesaurus term： Streptomyces

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JST classification (1)： Enzyme in general  (EB09010D)

Substance index (5)： Nordihydroguaiaretic acid ,  Tetrapetalone A ,  (2S)-2-Ethyl-4,5β,11-trimethyl-6α-(2,3,6-trideoxy-β-D-threo-hexopyranosyloxy)-9bβ-hydroxy-10-methoxy-2α,1-propeno-2,4aβ,5,6,8,9b-hexahydro-1H-indeno[7,1-bc]azepine-8,12-dione ,  (2S)-2-Ethyl-4,5β,11,11-tetramethyl-6α-(2,3,6-trideoxy-β-D-threo-hexopyranosyloxy)-9bβ-hydroxy-2α,1-propano-2,4aβ,5,6,8,9b-hexahydro-1H-indeno[7,1-bc]azepine-8,10,12-trione ,  TetraprtaloneA-Methyl aglycon

Reference (16)：

• 1) Samuelsson, B., Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science, 220, 568–575 (1983).
• 2) Ghosh, J., and Myers, C. E., Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer calls. Proc. Natl. Acad. Sci. U.S.A., 95, 13182–13187 (1998).
• 3) Bell, R. L., Young, P. R., Albert, D., Lanni, C., Summers, J. B., Brooks, D. W., Rubin, P., and Carter, G. W. I., The discovery and development of zileuton: an orally active 5-lipoxygenase inhibitor. Int. J. Immunopharmacol., 14, 505–510 (1992).
• 4) Safayhi, H., Mack, T., Sabieraj, J., Anozodo, M. I., Subramanian, L. R., and Ammon, E. P. T., Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase. J. Pharmacol. Exp. Ther., 261, 1143–1146 (1992).
• 5) Axelrod, B., Cheesbrough, T. M., and Laakso, S., Lipoxygense from soybeans. Methods Enzymol., 71, 441–451 (1981).

Terms in the title (3)： Streptomyces ,  リポキシゲナーゼ阻害剤 ,  テトラペタロンA