Art

J-GLOBAL ID：200902229856299987   Reference number：05A0564267

Determination of the absolute stereochemistry and asymmetric total synthesis of madindolines A and B: a practical improvement to a second-generation approach from the first-generation

マジンドリンA及びBの絶対立体化学の決定並びに不斉全合成 第一世代の方法から第二世代の方法への実用的な改良

Author (8)： HIROSE Tomoyasu (The Kitasato Inst., and Kitasato Inst. for Life Sci.s and Graduate School of Infection Control Sci.s and School of Ph・・・) ,  SUNAZUKA Toshiaki (The Kitasato Inst., and Kitasato Inst. for Life Sci.s and Graduate School of Infection Control Sci.s and School of Ph・・・) ,  YAMAMOTO Daisuke (The Kitasato Inst., and Kitasato Inst. for Life Sci.s and Graduate School of Infection Control Sci.s and School of Ph・・・) ,  KOJIMA Naoto (The Kitasato Inst., and Kitasato Inst. for Life Sci.s and Graduate School of Infection Control Sci.s and School of Ph・・・) ,  SHIRAHATA Tatsuya (The Kitasato Inst., and Kitasato Inst. for Life Sci.s and Graduate School of Infection Control Sci.s and School of Ph・・・) ,  HARIGAYA Yoshihiro (The Kitasato Inst., and Kitasato Inst. for Life Sci.s and Graduate School of Infection Control Sci.s and School of Ph・・・) ,  KUWAJIMA Isao (The Kitasato Inst., and Kitasato Inst. for Life Sci.s and Graduate School of Infection Control Sci.s and School of Ph・・・) ,  OMURA Satoshi (The Kitasato Inst., and Kitasato Inst. for Life Sci.s and Graduate School of Infection Control Sci.s and School of Ph・・・)
Material： Tetrahedron  (Tetrahedron Symposia-in-Print)
Volume： 61  Issue： 25  Page： 6015-6039  Publication year： Jun. 20, 2005 
JST Material Number： E0234A  ISSN： 0040-4020  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： absolute configuration ,...

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JST classification (2)： Alkaloids  (CF10030D) ,  Synthesis of drugs  (GV01030F)

Substance index (13)： (+)-Madindoline A ,  Tryptophol ,  3,3a,8,8aα-Tetrahydro-2H-furo[2,3-b]indole-3aα-ol ,  (3aR,8aS)-3a-[[(2S)-2-Methoxy-2-phenyl-3,3,3-trifluoropropionyl]oxy]-8-methyl-3,3a,8,8a-tetrahydro-2H-furo[2,3-b]indole ,  (4R)-2,2,5-Trimethyl-4α-vinyl-6α-isopropenyl-1,3-dioxane-5α-carboxylic acid methyl ester ,  5β-(tert-Butyldimethylsiloxy)-1,3-dimethyl-2-oxo-4-butyl-3-cyclopentene-1α-carboxylic acid methyl ester ,  (2R)-2-[3-(2-Hydroxyethyl)-1H-indole-1-ylmethyl]-2,4-dimethyl-5-butyl-4-cyclopentene-1,3-dione ,  rac-(2R^*)-2-Methyl-3-(pivaloyloxy)propanal ,  (αS)-α-Methyl-3aα-(tert-butyldimethylsiloxy)-3,3a,8,8aα-tetrahydro-2H-furo[2,3-b]indole-8-propionic acid methyl ester ,  (αS)-α-[(Z)-2-(Trimethylsilylmethyl)-2-heptenoyl]-α-methyl-3aα-(tert-butyldimethylsiloxy)-3,3a,8,8aα-tetrahydro-2H-furo[2,3-b]indole-8-propionic acid methyl ester ,  (2S,4Z)-2-[[(3aR,8aS)-3a-(tert-Butyldimethylsilyloxy)-3,3a,8,8a-tetrahydro-2H-furo[2,3-b]indole-8-yl]methyl]-2-methyl-3-oxo-4-[1-(trimethylsilyl)butyl]-4-hexenoic acid methyl ester ,  2-[[(3aR,8aS)-3a-Hydroxy-3,3a,8,8a-tetrahydro-2H-furo[2,3-b]indole-8-yl]methyl]-2-methyl-4-[(1,1-³H₂)butyl]-5-[(³H₂)methyl]-4-cyclopentene-1,3-dione ,  (+)-Madindoline B

Terms in the title (5)： マジンドリンA ,  立体化学 ,  不斉全合成 ,  一世代 ,  世代