Art

J-GLOBAL ID：200902230582672595   Reference number：08A0584688

Immunoreactivity of Phage Library-derived Human Single-Chain Antibodies to Amyloid Beta Conformers In Vitro

in vitroでのアミロイドベータ配座異性体に対するファージライブラリー由来のヒト一本鎖抗体の免疫反応性

Author (12)： YOSHIHARA Tomoki (Kagoshima Univ., Kagoshima) ,  TAKIGUCHI Sho (Kagoshima Univ., Kagoshima) ,  KYUNO Akifumi (Kagoshima Univ., Kagoshima) ,  TANAKA Koichi (Kagoshima Univ., Kagoshima) ,  KUBA Sayaka (Kagoshima Univ., Kagoshima) ,  HASHIGUCHI Shuhei (Kagoshima Univ., Kagoshima) ,  ITO Yuji (Kagoshima Univ., Kagoshima) ,  HASHIMOTO Tadafumi (Tokyo Univ., Tokyo) ,  IWATSUBO Takeshi (Tokyo Univ., Tokyo) ,  TSUYAMA Shinichiro (Kagoshima Univ., Kagoshima) ,  NAKASHIMA Toshihiro (Chemo-Sero-Therapeutic Res. Inst., Kumamoto, JPN) ,  SUGIMURA Kazuhisa (Kagoshima Univ., Kagoshima)
Material： Journal of Biochemistry  (JB)
Volume： 143  Issue： 4  Page： 475-486  Publication year： Apr. 01, 2008 
JST Material Number： W1920A  ISSN： 0021-924X  CODEN： JOBIAO  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： immunoglobulin fragment ,...
Semi thesaurus term： scFv ,...

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JST classification (2)： Proteins and peptides in general  (EB03010N) ,  Biochemistry of antigens,antibodies,complements  (ED04020L)

Reference (34)：

• KATZMAN, R. Advances in Alzheimer's disease. FASEB J. 1991, 5, 278-286
• LAMBERT, M. P. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc. Natl Acad. Sci. USA. 1998, 95, 6448-6453
• ROHER, A. E. Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease. J. Biol. Chem. 1996, 271, 20631-20635
• SYLVAIN, L. A specific amyloid-β protein assembly in the brain impairs memory. Nature. 2006, 440, 352-357
• HAASS, C. Amyloid β-peptide is produced by cultured cells during normal metabolism. Nature. 1992, 359, 322-325

Terms in the title (6)： アミロイドベータ ,  配座異性体 ,  ファージライブラリー ,  ヒト ,  一本鎖抗体 ,  免疫反応