Art

J-GLOBAL ID：200902230769034240   Reference number：03A0772630

Synthesis of a Highly Active New Anti-HIV Agent 2′,3′-Didehydro-3′-deoxy-4′-ethynylthymidine

非常に活性な新規抗HIV薬2′,3′-ジデヒドロ-3′-デオキシ-4′-エチニルチミジンの合成

Author (7)： HARAGUCHI K (Showa Univ., Tokyo, JPN) ,  TAKEDA S (Showa Univ., Tokyo, JPN) ,  TANAKA H (Showa Univ., Tokyo, JPN) ,  NITANDA T (Kagoshima Univ., Kagoshima, JPN) ,  BABA M (Kagoshima Univ., Kagoshima, JPN) ,  DUTSCHMAN G E (Yale Univ., CT, USA) ,  CHENG Y-C (Yale Univ., CT, USA)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 13  Issue： 21  Page： 3775-3777  Publication year： Nov. 03, 2003 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...

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JST classification (3)： Nucleosides,nucleotides  (CF10060K) ,  Synthesis of drugs  (GV01030F) ,  Basic research of antiviral drugs  (GW17040O)

Substance index (8)： 1-[(5R)-7β-(tert-Butyldimethylsiloxy)-1,4-dioxaspiro[2.4]heptane-5β-yl]thymine ,  3′β-(tert-Butyldimethylsiloxy)-3′-deoxythymidine ,  3′β-(tert-Butyldimethylsiloxy)-4′-vinyl-3′-deoxythymidine ,  3′β-(tert-Butyldimethylsiloxy)-4′-ethynyl-3′-deoxythymidine ,  3′β-(tert-Butyldimethylsiloxy)-4′-(hydroxymethyl)-5′-methylidyne-3′,5′-dideoxythymidine ,  4′-Methyl-2′,3′-didehydro-3′-deoxythymidine ,  4′-Vinyl-2′,3′-didehydro-3′-deoxythymidine ,  4′-Ed4T

Terms in the title (2)： 活性 ,  抗HIV薬