Art

J-GLOBAL ID：200902231299463102   Reference number：06A0720805

Fused protein of δPKC activation loop and PDK1-interacting fragment (δAL-PIF) functions as a pseudosubstrate and an inhibitory molecule for PDK1 when expressed in cells

δPKC活性ループおよびPDK1相互作用フラグメント(δAL-PIF)の融合蛋白質は,細胞内で発現するとPDK1の偽基質および阻害分子として機能する

Author (10)： SEKI Takahiro (Hiroshima Univ., Hiroshima, JPN) ,  IRIE Naoki (Kobe Univ., Kobe, JPN) ,  NAKAMURA Kyoko (Kobe Univ., Kobe, JPN) ,  SAKAUE Hiroshi (Kobe Univ., Kobe, JPN) ,  OGAWA Wataru (Kobe Univ., Kobe, JPN) ,  KASUGA Masato (Kobe Univ., Kobe, JPN) ,  YAMAMOTO Hideyuki (Kumamoto Univ., Kumamoto, JPN) ,  OHMORI Shiho (Kobe Univ., Kobe, JPN) ,  SAITO Naoaki (Kobe Univ., Kobe, JPN) ,  SAKAI Norio (Hiroshima Univ., Hiroshima, JPN)
Material： Genes to Cells  (Genes Cells)
Volume： 11  Issue： 9  Page： 1051-1070  Publication year： Sep. 2006 
JST Material Number： W0935A  ISSN： 1356-9597  CODEN： GECEFL  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： fusion protein ,...
Semi thesaurus term： *PDK1 ,...

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JST classification (1)： Biological function  (EB03040U)

Substance index (1)： adenosine triphosphate

Reference (51)：

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• Alessi, D. R., James, SR., Downes, C. P., Holmes, A. B., Gaffney, PR., Reese, C. B.& Cohen, P.(1997b) Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Ba. Curr. Biol.7, 261-269.
• Arico, S., Pattingre, S., Bauvy, C., Gane, P., Barbat, A., Codogno, P.& Ogier-Denis, E.(2002) Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line. J. Biol. Chem.277, 27613-27621.
• Balendran, A., Casamayor, A., Deak, M., Paterson, A., Gaffney, P., Currie, R., Downes, C. P.& Alessi, D. R.(1999) PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2. Curr. Biol.9, 393-404.

Terms in the title (12)： PKC ,  活性 ,  ループ ,  PDK1 ,  相互作用 ,  フラグメント ,  Al ,  融合蛋白質 ,  発現 ,  基質 ,  阻害 ,  分子