Art

J-GLOBAL ID：200902231517983644   Reference number：04A0153579

An efficient procedure for the resolution of α-cyano-α-fluoro-p-tolylacetic acid (CFTA) via the diastereomeric N-carbobenzyloxy-cis-1-amino-2-indanol esters.

ジアステレオマ性のN-カルボベンジルオキシ-cis-1-アミノ-2-インダノールエステル類を経由するα-シアノ-α-フルオロ-p-トリル酢酸(CFTA)の分割に対する効率的な処方

Author (6)： FUJIWARA T (Tohoku Univ., Sendai, JPN) ,  SASAKI M (Tohoku Univ., Sendai, JPN) ,  OMATA K (Tohoku Univ., Sendai, JPN) ,  KABUTO C (Tohoku Univ., Sendai, JPN) ,  KABUTO K (Tohoku Univ., Sendai, JPN) ,  TAKEUCHI Y (Toyama Medical and Pharmaceutical Univ., Toyama, JPN)
Material： Tetrahedron: Asymmetry  (Tetrahedron Asym)
Volume： 15  Issue： 3  Page： 555-563  Publication year： Feb. 09, 2004 
JST Material Number： T0907A  ISSN： 0957-4166  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *aromatic nitrile ,...
Semi thesaurus term： non-steroidal anti-inflammatory agent

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JST classification (3)： Aromatic monocyclic nitriles,isocyanides  (CF05210D) ,  Other separation methods  (CC01060D) ,  Indenes  (CF06030O)

Substance index (33)： N-(2β-Hydroxyindan-1β-yl)acetamide ,  (2β-Hydroxyindan-1β-yl)carbamic acid benzyl ester ,  (2α-Hydroxyindan-1α-yl)carbamic acid benzyl ester ,  rac-(R^*)-α-Cyano-α-fluoro-4-methylbenzeneacetic acid ethyl ester ,  Oxalyl chloride ,  α-Cyano-α-fluoro-4-methylbenzeneacetic acid (1R)-1β-(benzyloxycarbonylamino)-2,3-dihydro-1H-indene-2β-yl ester ,  (αS)-α-Cyano-α-fluoro-4-methylbenzeneacetic acid (1R)-1β-(benzyloxycarbonylamino)-2,3-dihydro-1H-indene-2β-yl ester ,  (αR)-α-Cyano-α-fluoro-4-methylbenzeneacetic acid (1R)-1β-(benzyloxycarbonylamino)-2,3-dihydro-1H-indene-2β-yl ester ,  (S)-2-Phenylpropionic acid ,  (R)-2-Phenylpropionic acid ,  (S)-Ibuprofen ,  (R)-Ibuprofen ,  Naproxen ,  (R)-Naproxen ,  (2S)-2-Phenylbutyric acid ,  (R)-2-Phenylbutyric acid ,  (S)-Methoxyphenylacetic acid ,  (R)-Methoxyphenylacetic acid ,  2-Phenylpropanoic acid chloride ,  2-(4-Isobutylphenyl)propionic acid chloride ,  α-Methyl-6-methoxynaphthalene-2-acetic acid chloride ,  2-Phenylbutyryl chloride ,  α-Methoxybenzeneacetic acid chloride ,  (αR)-α-Methylbenzeneacetic acid (1R)-1β-(acetylamino)-2,3-dihydro-1H-indene-2β-yl ester ,  (αS)-α-Methylbenzeneacetic acid (1R)-1β-(acetylamino)-2,3-dihydro-1H-indene-2β-yl ester ,  (αR)-α-Methyl-4-isobutylbenzeneacetic acid (1R)-1β-(acetylamino)-2,3-dihydro-1H-indene-2β-yl ester ,  (αS)-α-Methyl-4-isobutylbenzeneacetic acid (1R)-1β-(acetylamino)-2,3-dihydro-1H-indene-2β-yl ester ,  (αR)-α-Methyl-6-methoxynaphthalene-2-acetic acid (1R)-1β-(acetylamino)-2,3-dihydro-1H-indene-2β-yl ester ,  (αS)-α-Methyl-6-methoxynaphthalene-2-acetic acid (1R)-1β-(acetylamino)-2,3-dihydro-1H-indene-2β-yl ester ,  (αR)-α-Ethylbenzeneacetic acid (1R)-1β-(acetylamino)-2,3-dihydro-1H-indene-2β-yl ester ,  (αS)-α-Ethylbenzeneacetic acid (1R)-1β-(acetylamino)-2,3-dihydro-1H-indene-2β-yl ester ,  (αR)-α-Methoxybenzeneacetic acid (1R)-1β-(acetylamino)-2,3-dihydro-1H-indene-2β-yl ester ,  (αS)-α-Methoxybenzeneacetic acid (1R)-1β-(acetylamino)-2,3-dihydro-1H-indene-2β-yl ester

Terms in the title (6)： ジアステレオマ ,  cis-1-アミノ-2-インダノール ,  エステル類 ,  α-シアノ-α-フルオロ-p-トリル酢酸 ,  CFTA ,  処方