Art

J-GLOBAL ID：200902231633173811   Reference number：07A1094786

Edaravone inhibits the expression of vascular endothelial growth factor in human astrocytes exposed to hypoxia

エダラボンは低酸素に曝露したヒト星状細胞における血管内皮増殖因子の発現を阻害する

Author (9)： ISHIKAWA Akira (Dep. of Vascular Biology, Inst. of Brain Sci., Hirosaki Univ. School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, JPN) ,  YOSHIDA Hidemi (Dep. of Vascular Biology, Inst. of Brain Sci., Hirosaki Univ. School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, JPN) ,  METOKI Norifumi (Dep. of Internal Medicine, Hirosaki Stroke Center, 1-2-1 Ohgimachi, Hirosaki 036-8140, JPN) ,  TOKI Tsutomu (Dep. of Pediatrics, Hirosaki Univ. School of Medicine, Hirosaki 036-8562, JPN) ,  IMAIZUMI Tadaatsu (Dep. of Vascular Biology, Inst. of Brain Sci., Hirosaki Univ. School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, JPN) ,  MATSUMIYA Tomoh (Dep. of Vascular Biology, Inst. of Brain Sci., Hirosaki Univ. School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, JPN) ,  YAMASHITA Koji (Dep. of Physical Therapy, Fac. of Health Sciences, Aomori Univ. of Health and Welfare, 58-1 Hamadate-Mase, Aomori ...) ,  TAIMA Kageaki (The Second Dep. of Internal Medicine, Hirosaki Univ. School of Medicine, Hirosaki 036-8562, JPN) ,  SATOH Kei (Dep. of Vascular Biology, Inst. of Brain Sci., Hirosaki Univ. School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, JPN)
Material： Neuroscience Research  (神経科学)
Volume： 59  Issue： 4  Page： 406-412  Publication year： Dec. 2007 
JST Material Number： D0210C  ISSN： 0168-0102  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： VEGF ,...

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JST classification (2)： Basic research of other drugs acting on central nervous system  (GW03120U) ,  Central nervous system  (EJ12030F)

Substance index (1)： Edaravone

Reference (45)：

• Abe, K., Yuki, S., Kogure, K., 1988. Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger. Stroke 19, 480-485.
• Aizawa, H., Makita, Y., Sumitomo, K., Aburakawa, Y., Katayama, T., Nakatani-Enomoto, S., Suzuki, Y., Fujiwara, K., Enomoto, H., Kuroda, K., Kimura, T., Yahara, O., Koyama, S., Maruyama, J., Nakamura, M., Hasebe, N., Kikuchi, K., 2006. Edaravone diminishes free radicals from circulating neutrophils in patients with ischemic brain attack. Intern. Med. 45, 1-4.
• Bates, D.O., Curry, F.E., 1996. Vascular endothelial growth factor increases hydraulic conductivity of isolated perfused microvessels. Am. J. Physiol. Heart Circ. Physiol. 271, 2520-2528.
• Byrne, A.M., Bouchier-Hayes, D.J., Harmey, J.H., 2005. Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF). J. Cell. Mol. Med. 9, 777-794.
• Dery, M.-A.C., Michaud, M.D., Richard, D.E., 2005. Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators. Int. J. Biochem. Cell Biol. 37, 535-540.

Terms in the title (8)： エダラボン ,  低酸素 ,  曝露 ,  ヒト ,  星状細胞 ,  血管内皮増殖因子 ,  発現 ,  阻害