Art

J-GLOBAL ID：200902233425606367   Reference number：04A0128661

Molecular Mechanism of the Drop in the pK_a of a Substrate Analog Bound to Medium-Chain Acyl-CoA Dehydrogenase: Implications for Substrate Activation

中鎖アシルCoAデヒドロゲナーゼに結合する基質アナログのpK_a低下の分子メカニズム:基質活性化への関与

Author (7)： NISHINA Y (Kumamoto Univ., Kumamoto) ,  SATO K (Kumamoto Univ., Kumamoto) ,  TAMAOKI H (Kumamoto Univ., Kumamoto) ,  TANAKA T (Kobe Univ., Kobe) ,  SETOYAMA C (Kumamoto Univ., Kumamoto) ,  MIURA R (Kumamoto Univ., Kumamoto) ,  SHIGA K (Kumamoto Univ., Kumamoto)
Material： Journal of Biochemistry  (J Biochem)
Volume： 134  Issue： 6  Page： 835-842  Publication year： Dec. 01, 2003 
JST Material Number： F0286A  ISSN： 0021-924X  CODEN： JOBIAO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *acyl-CoA dehydrogenase ,...
Semi thesaurus term： pKa

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=04A0128661&from=J-GLOBAL&jstjournalNo=F0286A") }}

JST classification (1)： Enzyme in general  (EB09010D)

Substance index (3)： FAD ,  Acetoacetyl-CoA ,  3S-C8-CoA

Reference (45)：

• CRANE, F. L. On the mechanism of dehydrogenase of fatty acyl derivatives of coenzyme A. I. The general fatty acyl coenzyme A dehydrogenase. J. Biol. Chem. 1956, 218, 701-716
• ENGEL, P. C. Acyl-coenzyme A dehydrogenases in Chemistry and Biochemistry of Flavoenzymes. 1992, III, 597-655
• GHISLA, S. Mechanistic studies with general acyl-CoA dehydrogenase and butyryl-CoA dehydrogenase : Evidence for the transfer of β-hydrogen to the flavin N(5)-position as a hydride. Biochemistry. 1984, 23, 3154-3161
• FENDRICH, G. Mechanism of action of butyryl-CoA dehydrogenase : Reactions with acetylenic, olefinic, and fluorinated substrate analogues. Biochemistry. 1982, 21, 6685-6695
• THORPE, C. Green enzymes and suicide substrates : A look at the acyl-CoA dehydrogenases in fatty acid oxidation. Trends Biochem. Sci. 1989, 14, 148-151

Terms in the title (6)： アシルCoAデヒドロゲナーゼ ,  基質 ,  アナログ ,  pKa ,  分子メカニズム ,  活性化