Analgesic action of loperamide, an opioid agonist, and its blocking action on voltage-dependent Ca<sup>2+</sup> channels.

HAGIWARA K; NAKAGAWASAI O; MURATA A; MIYOSHI I; TAN-NO K; TADANO T; YANAGISAWA T; IIJIMA T; MURAKAMI M

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J-GLOBAL ID：200902234361491397 Reference number：03A0566206

Analgesic action of loperamide, an opioid agonist, and its blocking action on voltage-dependent Ca²⁺ channels.

オピオイド作動薬ロペラミドの鎮痛作用とCa²⁺チャンネル阻害作用

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Material：
Volume： 46 Issue： 4 Page： 493-497 Publication year： Aug. 2003
JST Material Number： D0210C ISSN： 0168-0102 Document type： Article
Article type：原著論文 Country of issue： Netherlands (NLD) Language： ENGLISH (EN)

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Basic neurology , Basic research of addictive analgesics and narcotics

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Reference (14)：

CHURCH, J. Loperamide blocks high-voltage-activated calcium channels and N-methyl-D-aspartate-evoked responses in rat and mouse cultured hippocampal pyramidal neurons. Mol. Pharmacol. 1994, 45, 747-757
DEHAVEN-HUDKINS, D. L. Loperamide (ADL-1294), an opioid antihyperalgesic agent with peripheral selectivity. J. Pharmacol. Exp. Ther. 1999, 289, 327-333
DUBUISSON, D. The formalin test : a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain. 1977, 4, 161-174
FUJII, S. Effect of cilnidipine, a novel dihydropyridine Ca^<2+>-channel antagonist, on N-type Ca^<2+> channel in rat dorsal root ganglion neurons. J. Pharmacol. Exp. Ther. 1997, 280, 1184-1191
GOHIL, K. Neuroanatomical distribution of receptors for a novel voltage-sensitive calcium channel antagonist, SNX-230 (ω-conopeptide MVIIC). Brain Res. 1994, 653, 258-266

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Analgesic action of loperamide, an opioid agonist, and its blocking action on voltage-dependent Ca2+ channels.

Analgesic action of loperamide, an opioid agonist, and its blocking action on voltage-dependent Ca²⁺ channels.