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J-GLOBAL ID：200902234365091423   Reference number：07A0635323

Establishment of a GDP-mannose 4,6-dehydratase (GMD) knockout host cell line: A new strategy for generating completely non-fucosylated recombinant therapeutics

GDP-マンノース4,6-デヒドラターゼ(GMD)ノックアウト宿主細胞株の確立:完全非フコシル化組換治療学を産生するための新戦略

Author (10)： KANDA Yutaka (Tokyo Res. Laboratories, Kyowa Hakko Kogyo Co. Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, JPN) ,  IMAI-NISHIYA Harue (Tokyo Res. Laboratories, Kyowa Hakko Kogyo Co. Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, JPN) ,  KUNI-KAMOCHI Reiko (Tokyo Res. Laboratories, Kyowa Hakko Kogyo Co. Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, JPN) ,  MORI Katsuhiro (Tokyo Res. Laboratories, Kyowa Hakko Kogyo Co. Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, JPN) ,  INOUE Miho (Tokyo Res. Laboratories, Kyowa Hakko Kogyo Co. Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, JPN) ,  KITAJIMA-MIYAMA Kazuko (Tokyo Res. Laboratories, Kyowa Hakko Kogyo Co. Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, JPN) ,  OKAZAKI Akira (Tokyo Res. Laboratories, Kyowa Hakko Kogyo Co. Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, JPN) ,  IIDA Shigeru (Tokyo Res. Laboratories, Kyowa Hakko Kogyo Co. Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, JPN) ,  SHITARA Kenya (Tokyo Res. Laboratories, Kyowa Hakko Kogyo Co. Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, JPN) ,  SATOH Mitsuo (Tokyo Res. Laboratories, Kyowa Hakko Kogyo Co. Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, JPN)
Material： Journal of Biotechnology  (Reviews in Molecular Biotechnology)
Volume： 130  Issue： 3  Page： 300-310  Publication year： Jun. 30, 2007 
JST Material Number： A0456C  ISSN： 0168-1656  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *hydrolyase ,...
Semi thesaurus term： *CHO/DG44細胞 ,...

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JST classification (3)： Production and application of antigens,antibodies,complements  (ED04030W) ,  Substance production by animal tissues and cells  (FK03060S) ,  Carbohydrates and sugar chains in general  (EB06010I)

Substance index (2)： GDP-fucose ,  Fucose

Terms in the title (9)： GDP-マンノース ,  デヒドラターゼ ,  ノックアウト ,  宿主 ,  細胞株 ,  フコシル化 ,  組換 ,  治療学 ,  戦略