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J-GLOBAL ID：200902234482931483   Reference number：09A0758850

DIHYDROCHALCONE DESIGNED FROM METHYLOPHIOPOGONANONE B STRONGLY INHIBITS HYPOXIA-INDUCIBLE FACTOR (HIF)-1α ACTIVITY

メチルオフィオポゴナノンBから設計したジヒドロカルコンによる強い低酸素誘導性因子(HIF)-1α活性の阻害

Author (13)： FUJII Mikio (Showa Univ., Tokyo, JPN) ,  FUJII Mikio (Toho Univ., Chiba, JPN) ,  EGAWA Kiyoshi (Showa Univ., Tokyo, JPN) ,  HIRAI Yasuaki (Showa Univ., Tokyo, JPN) ,  KONDO Masato (Showa Univ., Tokyo, JPN) ,  KONDO Masato (Showa Univ., Yokohama, JPN) ,  FUJII Kotaro (Tokyo Inst. for Technol., Tokyo) ,  UEKUSA Hidehiro (Tokyo Inst. for Technol., Tokyo) ,  AKITA Hiroyuki (Toho Univ., Chiba, JPN) ,  NOSE Kiyoshi (Showa Univ., Tokyo, JPN) ,  TORIIZUKA Kazuo (Showa Univ., Tokyo, JPN) ,  IDA Yoshiteru (Showa Univ., Tokyo, JPN) ,  IDA Yoshiteru (Yokohama Coll. of Pharmacy, Yokohama)
Material： Heterocycles  (International Journal for Reviews and Communications in Heterocyclic Chemistry)
Volume： 78  Issue： 8  Page： 2061-2065  Publication year： Aug. 01, 2009 
JST Material Number： S0966A  ISSN： 0385-5414  CODEN： HTCYAM  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *transcription factor ,...
Semi thesaurus term： *inhibitor ,...

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JST classification (3)： Condensed derivatives of pyrane  (CF07093I) ,  Synthesis of drugs  (GV01030F) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (11)： 1-(2-Hydroxy-3,5-dimethyl-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)propane-1-one ,  1-(2-Hydroxy-3,5-dimethyl-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-2-propene-1-one ,  1-(2-Hydroxy-3,5-dimethyl-4,6-dimethoxyphenyl)-3-[4-(dimethylamino)phenyl]propane-1-one ,  1-(2-Hydroxy-3,5-dimethyl-4,6-dimethoxyphenyl)-3-phenylpropane-1-one ,  1-(2-Hydroxy-3,5-dimethyl-4,6-dimethoxyphenyl)-3-phenyl-2-propene-1-one ,  2′-Hydroxy-4′,6′-dimethoxy-ω-(4-methoxyphenyl)propiophenone ,  1-(2-Hydroxy-4,6-dimethoxy-5-methylphenyl)-3-(4-methoxyphenyl)propane-1-one ,  rac-(3R^*)-3-(4-Hydroxybenzyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydro-4H-1-benzopyran-4-one ,  rac-(3R^*)-3-(4-Methoxybenzyl)-5,7-dimethoxy-6,8-dimethyl-2,3-dihydro-4H-1-benzopyran-4-one ,  rac-(3R^*)-3-(4-Methoxybenzyl)-5-hydroxy-6,8-dimethyl-7-methoxy-2,3-dihydro-4H-1-benzopyran-4-one ,  Methylophiopogonanone B

Reference (16)：

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Terms in the title (8)： メチルオフィオポゴナノンB ,  設計 ,  低酸素 ,  誘導 ,  性因子 ,  HIF ,  活性 ,  阻害