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J-GLOBAL ID：200902234922829961   Reference number：06A0457823

Quantitative magnetic resonance spectroscopy of schizophrenia: Relationship between decreased N-acetylaspartate and frontal lobe dysfunction

統合失調症の定量的MRS:N-アセチルアスパラギン酸と前頭葉機能障害の関連性

Author (13)： TANAKA Yoko (Tokyo Medical and Dental Univ. School of Medicine, Tokyo) ,  TANAKA Yoko (Asai Hospital) ,  TANAKA Yoko (National Inst. of Radiological Sci., Chiba) ,  OBATA Takayuki (National Inst. of Radiological Sci., Chiba) ,  SASSA Takeshi (Asai Hospital) ,  SASSA Takeshi (National Inst. of Radiological Sci., Chiba) ,  YOSHITOME Eiji (National Inst. of Radiological Sci., Chiba) ,  ASAI Yoshiyuki (Asai Hospital) ,  ASAI Yoshiyuki (National Inst. of Radiological Sci., Chiba) ,  IKEHIRA Hiroo (National Inst. of Radiological Sci., Chiba) ,  SUHARA Tetsuya (National Inst. of Radiological Sci., Chiba) ,  OKUBO Yoshiro (Nippon Medical School, Tokyo, JPN) ,  NISHIKAWA Toru (Tokyo Medical and Dental Univ. School of Medicine, Tokyo)
Material： Psychiatry and Clinical Neurosciences  (Psychiatry Clin Neurosci)
Volume： 60  Issue： 3  Page： 365-372  Publication year： Jun. 2006 
JST Material Number： W1032A  ISSN： 1323-1316  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： proton magnetic resonance ,...
Semi thesaurus term： *schizophrenia ,...

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JST classification (1)： Mental disorders  (GR03000A)

Substance index (4)： N-Acetylaspartic acid ,  Creatine ,  Choline ,  Phosphocreatine

Reference (39)：

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• Miller BL, Chang L, Booth R et al.In vivo 1H MRS choline: correlation with in vitro chemistry/histology.Life Sci.1996; 58: 1929-1935.
• McGlashan TH.The profiles of clinical deterioration in schizophrenia.J.Psychiatr.Res.1998; 32: 133-141.
• Okubo Y, Suhara T, Suzuki K, Kobayashi K, Inoue O, Terasaki O.Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET.Nature 1997; 385: 634-636.
• Moreno-Iniguez M, Ortuno F, Arbizu J, Millan M, Soutullo C, Cervera S.Regional cerebral blood flow SPECT study, at rest and during Wisconsin Card Sorting Test (WCST) performance, in schizophrenia naive patients or treated with atypical neurolpetics.Acta Esp. Psiquiatr.2005; 33: 352-358.

Terms in the title (6)： 統合失調症 ,  定量 ,  MRS ,  N-アセチルアスパラギン酸 ,  前頭葉機能障害 ,  関連性