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J-GLOBAL ID：200902235502764488   Reference number：09A0210192

O-Mannosylation is required for the solubilization of heterologously expressed human β-amyloid precursor protein in Saccharomyces cerevisiae

Saccharomyces cerevisiaeにおいて発現したヒトβアミロイド前駆体蛋白質の可溶化にO-マンノシル化が必要である

Author (6)： MURAKAMI-SEKIMATA Akiko (RIKEN, Saitama, JPN) ,  SATO Ken (RIKEN, Saitama, JPN) ,  SATO Ken (RIKEN, Saitama, JPN) ,  TAKASHIMA Akihiko (RIKEN, Saitama, JPN) ,  NAKANO Akihiko (RIKEN, Saitama, JPN) ,  NAKANO Akihiko (Univ. Tokyo, Tokyo, JPN)
Material： Genes to Cells  (Genes Cells)
Volume： 14  Issue： 2  Page： 205-215  Publication year： Feb. 2009 
JST Material Number： W0935A  ISSN： 1356-9597  CODEN： GECEFL  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： *Saccharomyces cerevisiae ,...
Semi thesaurus term： GPI-anchor ,...

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JST classification (1)： Proteins and peptides in general  (EB03010N)

Reference (34)：

• Beltran-Valero de Bernabe, D., Currier, S., Steinbrecher, A. et al . (2002) Mutations in the O-mannosyltransferase gene POMT1 give rise to the severe neuronal migration disorder walker-warburg syndrome. Am. J. Hum. Genet. 71, 1033-1043.
• Chai, W., Yuen, C.T., Kogelberg, H., Carruthers, R.A., Margolis, R.U., Feizi, T. & Lawson, A. M. (1999) High prevalence of 2-mono- and 2,6-di-substituted manol-terminating sequences among O-glycans released from brain glycopeptides by reductive alkaline hydrolysis. Eur. J. Biochem. 263, 879-888.
• Ecker, M., Mrsa, V., Hagen, I., Deutzmann, R., Strahl, S. & Tanner, W. (2003) O-mannosylation precedes and potentially controls the N-glycosylation of a yeast cell wall glycoprotein. EMBO J. 4, 628-632.
• Endo, T. (1999) O-mannosyl glycans in mammals. Biochim. Biophys. Acta 1473, 237-246.
• Gentzsch, M. & Tanner, W. (1996) The PMT gene family: protein O-glycosylation in Saccharomyces cerevisiae is vital. EMBO J. 15, 5752-5759.

Terms in the title (6)： Saccharomyces ,  発現 ,  ヒト ,  βアミロイド前駆体蛋白質 ,  可溶化 ,  マンノシル化