Art

J-GLOBAL ID：200902235579151667   Reference number：06A0676217

Strategy for Discovering Chemical Inhibitors of Human Cyclophilin A: Focused Library Design, Virtual Screening, Chemical Synthesis and Bioassay

ヒト型シクロフィリンAの化学阻害剤を発見するための戦略 焦点合わせライブラリー設計,実質的スクリーニング,化学合成及びバイオアッセイ

Author (11)： LI Jian (Shanghai Inst. for Biological Sci., Chinese Acad. of Sci., Shanghai, CHN) ,  ZHANG Jian (Shanghai Inst. for Biological Sci., Chinese Acad. of Sci., Shanghai, CHN) ,  CHEN Jing (Shanghai Inst. for Biological Sci., Chinese Acad. of Sci., Shanghai, CHN) ,  LUO Xiaomin (Shanghai Inst. for Biological Sci., Chinese Acad. of Sci., Shanghai, CHN) ,  ZHU Weiliang (Shanghai Inst. for Biological Sci., Chinese Acad. of Sci., Shanghai, CHN) ,  SHEN Jianhua (Shanghai Inst. for Biological Sci., Chinese Acad. of Sci., Shanghai, CHN) ,  LIU Hong (Shanghai Inst. for Biological Sci., Chinese Acad. of Sci., Shanghai, CHN) ,  SHEN Xu (Shanghai Inst. for Biological Sci., Chinese Acad. of Sci., Shanghai, CHN) ,  SHEN Xu (East China Univ. Sci. and Technol., Shanghai, CHN) ,  JIANG Hualiang (Shanghai Inst. for Biological Sci., Chinese Acad. of Sci., Shanghai, CHN) ,  JIANG Hualiang (East China Univ. Sci. and Technol., Shanghai, CHN)
Material： Journal of Combinatorial Chemistry  (J Comb Chem)
Volume： 8  Issue： 3  Page： 326-337  Publication year： May. 2006 
JST Material Number： W1756A  ISSN： 1520-4766  CODEN： JCCHFF  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： PPIアーゼ

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JST classification (1)： Structure-activity relationship of drugs  (GV01050B)

Substance index (14)： (3S)-N-tert-Butyl-2-[2-(3-chlorophenyl)-4-quinolinylmethyl]-1,2,3,4-tetrahydroisoquinoline-3α-carboxamide ,  (3S)-N-tert-Butyl-2-[2-(2-naphthyl)-4-quinolinylmethyl]-1,2,3,4-tetrahydroisoquinoline-3α-carboxamide ,  2-(2-Naphthyl)-4-(piperidinomethyl)quinoline ,  (3R)-1-[2-(2-Naphthyl)-4-quinolinylmethyl]piperidine-3α-carboxylic acid ethyl ester ,  N,N-Diethyl-N²-[2-(2-naphthyl)-4-quinolinylmethyl]glycinamide ,  2-(2-Naphthyl)-4-quinolinylcarbamic acid isopentyl ester ,  (3R)-1-[2-(3-Chlorophenyl)-4-quinolinylcarbamoyl]piperidine-3α-carboxylic acid ethyl ester ,  2-(Benzylamino)-5-[2-(3-chlorophenyl)-4-quinolinylcarbamoyl]benzoic acid methyl ester ,  2-(Benzylamino)-5-[4-(3,4-dimethyl-5-isoxazolylsulfamoyl)phenylcarbamoyl]benzoic acid methyl ester ,  N-[3-(Methoxycarbonyl)-4-(benzylamino)phenyl]-2,3-di(2-furanyl)quinoxaline-6-carboxamide ,  N-[4-(4-Methyl-2-pyrimidinylsulfamoyl)phenyl]-2,3-di(2-furanyl)quinoxaline-6-carboxamide ,  N-[4-(5-Methyl-3-isoxazolylsulfamoyl)phenyl]-2,3-di(2-furanyl)quinoxaline-6-carboxamide ,  N-[4-(2-Pyrimidinylsulfamoyl)phenyl]-2,3-di(2-furanyl)quinoxaline-6-carboxamide ,  N-[4-(2-Quinoxalinylsulfamoyl)phenyl]-2,3-di(2-furanyl)quinoxaline-6-carboxamide

Terms in the title (12)： ヒト ,  シクロフィリンA ,  化学 ,  阻害剤 ,  発見 ,  戦略 ,  焦点合わせ ,  ライブラリー ,  設計 ,  スクリーニング ,  化学合成 ,  バイオアッセイ