Art

J-GLOBAL ID：200902236065800760   Reference number：03A0331361

Macrocyclic Inhibitors of the NS3 Protease as Potential Therapeutic Agents of Hepatitis C Virus Infection

C型肝炎ウイルス感染症の有力な治療薬としてのNS3プロテアーゼの大環状環阻害剤

Author (9)： TSANTRIZOS Y (Boehringer Ingelheim (Canada) Ltd., PQ, CAN) ,  BOLGER G (Boehringer Ingelheim (Canada) Ltd., PQ, CAN) ,  BONNEAU P (Boehringer Ingelheim (Canada) Ltd., PQ, CAN) ,  CAMERON D R (Boehringer Ingelheim (Canada) Ltd., PQ, CAN) ,  GOUDREAU N (Boehringer Ingelheim (Canada) Ltd., PQ, CAN) ,  KUKOLJ G (Boehringer Ingelheim (Canada) Ltd., PQ, CAN) ,  LAPLANTE S R (Boehringer Ingelheim (Canada) Ltd., PQ, CAN) ,  NAR H (Boehringer Ingelheim Pharma KG, Biberach, DEU) ,  LAMARRE D (Boehringer Ingelheim (Canada) Ltd., PQ, CAN)
Material： Angewandte Chemie. International Edition  (Angewandte Chemie. International Edition in English)
Volume： 42  Issue： 12  Page： 1356-1360  Publication year： Mar. 28, 2003 
JST Material Number： H0127B  ISSN： 1433-7851  CODEN： ACIEAY  Document type： Article
Article type： 短報  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： Replicon ,...

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JST classification (2)： Peptides  (CF10080G) ,  Enzyme in general  (EB09010D)

Substance index (6)： Acetaldehyde ,  1-Propanol ,  (2S,5R,6S,7Z,14S)-1,2-Propano-5,6-methano-3,15-dioxo-14-(tert-butyloxycarbonylamino)-1,4-diazacyclohexadeca-7-ene-5-carboxylic acid ,  (2S,5R,6S,7Z,14S,18R)-1,2-Propano-5,6-methano-3,15-dioxo-14-(tert-butyloxycarbonylamino)-18-(7-methoxy-4-quinolyloxy)-1,4-diazacyclopentadeca-7-ene-5-carboxylic acid ,  (1S,4R,6S,7Z,14S,18R)-2,15-Dioxo-14-[(tert-butyloxycarbonyl)amino]-18-[(2-phenyl-7-methoxy-4-quinolinyl)oxy]-3,16-diazatricyclo[14.3.0.0^4,6]nonadeca-7-ene-4-carboxylic acid ,  (2S,5R,6R,14S,18R)-1,2-Propano-5,6-methano-3,15-dioxo-14-(tert-butyloxycarbonylamino)-18-(2-phenyl-7-methoxy-4-quinolyloxy)-1,4-diazacyclopentadecane-5-carboxylic acid

Terms in the title (7)： C型肝炎ウイルス感染症 ,  治療薬 ,  NS3 ,  プロテアーゼ ,  環状 ,  環 ,  阻害剤