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J-GLOBAL ID：200902236794987276   Reference number：09A0383466

Knockdown of Severe Acute Respiratory Syndrome Corona Virus (SARS-CoV) Genes by Small Interfering RNA (siRNA) Using siRNA-expression Vectors and Synthetic Double-stranded RNA (dsRNA) as a Model for siRNA Design

siRNAデザインモデルとしてsiRNA発現ベクターおよび合成二本鎖RNA(dsRNA)を用いた重症急性呼吸器症候群コロナウイルス(SARS-CoV)遺伝子のノックダウン

Author (8)： SUTOU Shizuyo (School of Pharmacy, Shujitsu Univ.) ,  KUNISHI Miho (School of Pharmacy, Shujitsu Univ.) ,  KUDO Toshiyuki (School of Pharmacy, Shujitsu Univ.) ,  KAWANO Kenji (iGENE Therapeutics Inc.) ,  TAKAGI Yasuomi (iGENE Therapeutics Inc.) ,  SIERANT Malgorzata (Centre of Molecular and Macromolecular Studies, Polish Acad. of Sciences, Dep. of Bioorganic Chemistry) ,  SANO Masayuki (Biotherapeutic Res. Lab., National Inst. of Advanced Industrial Sci. and Technol. (AIST)) ,  MIYAGISHI Makoto (Dep. of Gene Diagnostics and Therapeutics, Res. Inst., International Medical Center of Japan)
Material： Genes and Environment  (Genes Environ)
Volume： 31  Issue： 1  Page： 15-23 (J-STAGE)  Publication year： 2009 
JST Material Number： X0839A  ISSN： 1880-7046  CODEN： GEENGP  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Coronaviridae ,...
Semi thesaurus term： *SARS-associated coronavirus ,...

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JST classification (2)： Gene manipulation  (EC02050B) ,  Virus biochemistry  (EG04030F)

Reference (31)：

• DROSTEN, C. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Eng J Med. 2003, 348, 1967-1976
• DING, Y. The clinical pathology of severe acute respiratory syndrome (SARS) : a report from China. J Pathol. 2003, 200, 282-289
• SARS. What have we learned?. Nature. 2003, 424, 121-126
• FIRE, A. Potent and specific genetic interference by double stranded RNA in Caenorhabditis elegans. Nature. 1998, 391, 806-811
• ELBASHIR, SM. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 2001, 411, 494-498

Terms in the title (10)： siRNA ,  デザイン ,  モデル ,  発現ベクター ,  二本鎖RNA ,  dsRNA ,  重症急性呼吸器症候群 ,  コロナウイルス ,  遺伝子 ,  ノックダウン