Overexpression of Cu-Zn superoxide dismutase protects neuroblastoma cells against dopamine cytotoxicity accompanied by increase in their glutathione level

HAQUE M E; ASANUMA M; HIGASHI Y; MIYAZAKI I; TANAKA K; OGAWA N

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J-GLOBAL ID：200902237448055258 Reference number：03A0678542

Overexpression of Cu-Zn superoxide dismutase protects neuroblastoma cells against dopamine cytotoxicity accompanied by increase in their glutathione level

Cu-Znスーパーオキシドジスムターゼの過剰発現によりグルタチオン濃度が上昇してドーパミン細胞毒性から神経芽細胞が保護される

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Material：
Volume： 47 Issue： 1 Page： 31-37 Publication year： Sep. 2003
JST Material Number： D0210C ISSN： 0168-0102 Document type： Article
Article type：原著論文 Country of issue： Netherlands (NLD) Language： ENGLISH (EN)

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Nervous system in general , Cell physiology in general

Reference (21)：

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ASANUMA, M. Attenuation of 6-hydroxydopamine-induced dopaminergic nigrostriatal lesions in superoxide dismutase transgenic mice. Neuroscience. 1998, 85, 907-917
ASANUMA, M. Dopamine- or L-DOPA-induced neurotoxicity : the role of dopamine quinone formation and tyrosinase in a model of Parkinson's disease. Neurotox. Res. 2003, 5, 165-175
BAEZ, S. Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes. Biochem. J. 1997, 324, 25-28
BARKATS, M. Neuronal transfer of the human Cu/Zn superoxide dismutase gene increases the resistance of dopaminergic neurons to 6-hydroxydopamine. J. Neurochem. 2002, 82, 101-109

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