Art

J-GLOBAL ID：200902237528088262   Reference number：09A1236801

siRNA-mediated knockdown against CDCA1 and KNTC2, both frequently overexpressed in colorectal and gastric cancers, suppresses cell proliferation and induces apoptosis

結腸直腸および胃癌でしばしば過剰発現しているCDCA1とKNTC2に対するsiRNAが仲介するノックダウンは細胞増殖を抑制しアポトーシスを誘導する

Author (17)： KANEKO Naoyuki (Dep. of Molecular Pathology, Tohoku Univ. School of Medicine, Sendai, Miyagi 980-8575, JPN) ,  KANEKO Naoyuki (Dep. of Surgery, Tohoku Univ. School of Medicine, Sendai, Miyagi 980-8575, JPN) ,  MIURA Koh (Dep. of Surgery, Tohoku Univ. School of Medicine, Sendai, Miyagi 980-8575, JPN) ,  GU Zhaodi (Dep. of Molecular Pathology, Tohoku Univ. School of Medicine, Sendai, Miyagi 980-8575, JPN) ,  KARASAWA Hideaki (Dep. of Surgery, Tohoku Univ. School of Medicine, Sendai, Miyagi 980-8575, JPN) ,  OHNUMA Shinobu (Dep. of Surgery, Tohoku Univ. School of Medicine, Sendai, Miyagi 980-8575, JPN) ,  SASAKI Hiroyuki (Dep. of Surgery, Tohoku Univ. School of Medicine, Sendai, Miyagi 980-8575, JPN) ,  TSUKAMOTO Nobukazu (Dep. of Molecular Pathology, Tohoku Univ. School of Medicine, Sendai, Miyagi 980-8575, JPN) ,  TSUKAMOTO Nobukazu (Dep. of Surgery, Tohoku Univ. School of Medicine, Sendai, Miyagi 980-8575, JPN) ,  YOKOYAMA Satoru (Dep. of Molecular Pathology, Tohoku Univ. School of Medicine, Sendai, Miyagi 980-8575, JPN) ,  YOKOYAMA Satoru (Dep. of Surgery, Tohoku Univ. School of Medicine, Sendai, Miyagi 980-8575, JPN) ,  YAMAMURA Akihiro (Dep. of Molecular Pathology, Tohoku Univ. School of Medicine, Sendai, Miyagi 980-8575, JPN) ,  YAMAMURA Akihiro (Dep. of Surgery, Tohoku Univ. School of Medicine, Sendai, Miyagi 980-8575, JPN) ,  NAGASE Hiroki (Div. of Cancer Genetics, Dep. of Advanced Medical Sci., Nihon Univ. School of Medicine, Itabashi-ku, Tokyo 173-8610, JPN) ,  SHIBATA Chikashi (Dep. of Surgery, Tohoku Univ. School of Medicine, Sendai, Miyagi 980-8575, JPN) ,  SASAKI Iwao (Dep. of Surgery, Tohoku Univ. School of Medicine, Sendai, Miyagi 980-8575, JPN) ,  HORII Akira (Dep. of Molecular Pathology, Tohoku Univ. School of Medicine, Sendai, Miyagi 980-8575, JPN)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 390  Issue： 4  Page： 1235-1240  Publication year： Dec. 25, 2009 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： colonic neoplasm ,  rectal neoplasm ,  *stomach tumor ,  siRNA ,  inhibition of multiplication ,  *Apoptosis ,  *Proteins ,  Cell Cycle ,  Ndc80 ,  Cell Cycle Checkpoints
Semi thesaurus term： colorectal cancer ,  *CDCA1 ,  *KNTC2 ,  SPC24 ,  SPC25

JST classification (1)： Tumors(=neoplasms)of digestive system  (GH04000D)

Terms in the title (9)： 結腸直腸 ,  胃癌 ,  過剰発現 ,  siRNA ,  仲介 ,  ノックダウン ,  細胞増殖 ,  アポトーシス ,  誘導