Art

J-GLOBAL ID：200902237568721502   Reference number：08A0416242

Reliable assignment of absolute configuration of chiral amines based on the analysis of ¹H NMR spectra of their CFTA amide diastereomers

CFTAアミドジアステレオマの¹H-NMRスペクトルの解析に基づくキラルアミン類の信頼性ある絶対配置の帰属

Author (10)： FUJIWARA Tomoya (Graduate School of Medicine and Pharmaceutical Sciences for Res., Univ. of Toyama, Sugitani 2630, Toyama 930-0194, JPN) ,  SEGAWA Masaru (Graduate School of Medicine and Pharmaceutical Sciences for Res., Univ. of Toyama, Sugitani 2630, Toyama 930-0194, JPN) ,  FUJISAWA Hidehito (Graduate School of Medicine and Pharmaceutical Sciences for Res., Univ. of Toyama, Sugitani 2630, Toyama 930-0194, JPN) ,  MURAI Taiki (Graduate School of Medicine and Pharmaceutical Sciences for Res., Univ. of Toyama, Sugitani 2630, Toyama 930-0194, JPN) ,  TAKAHASHI Tamiko (Graduate School of Medicine and Pharmaceutical Sciences for Res., Univ. of Toyama, Sugitani 2630, Toyama 930-0194, JPN) ,  OMATA Kenji (Dep. of Chemistry, Graduate School of Sci., Tohoku Univ., Aramaki, Aoba-ku, Sendai 980-8578, JPN) ,  KABUTO Kuninobu (Dep. of Chemistry, Graduate School of Sci., Tohoku Univ., Aramaki, Aoba-ku, Sendai 980-8578, JPN) ,  LODWIG Siegfried N. (National Stable Isotope Resource, Bioscience Div., MS E529, Los Alamos National Lab., Los Alamos, NM 87544, USA) ,  UNKEFER Clifford J. (National Stable Isotope Resource, Bioscience Div., MS E529, Los Alamos National Lab., Los Alamos, NM 87544, USA) ,  TAKEUCHI Yoshio (Graduate School of Medicine and Pharmaceutical Sciences for Res., Univ. of Toyama, Sugitani 2630, Toyama 930-0194, JPN)
Material： Tetrahedron: Asymmetry  (Tetrahedron Asym)
Volume： 19  Issue： 7  Page： 847-856  Publication year： Apr. 17, 2008 
JST Material Number： T0907A  ISSN： 0957-4166  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *aliphatic amine ,  absolute configuration ,  carboxamide ,  diastereomer ,  NMR ,  optical isomerism ,  labeling method ,  amino acid
Semi thesaurus term： Isotope Labeling

JST classification (2)： Aliphatic amines,imines,quaternary ammonium,immonium compounds  (CF03070L) ,  Configuration and conformation of molecules  (BH05022J)

Substance index (24)： CFTA ,  (S)-α-Cyano-α-fluoro-4-methylbenzeneacetic acid ,  (S)-α-Fluoro-α-cyano-N-[(S)-sec-butyl]-4-methylbenzeneacetamide ,  (S)-α-Fluoro-α-cyano-N-[(R)-1,2-dimethylpropyl]-4-methylbenzeneacetamide ,  (S)-α-Fluoro-α-cyano-N-[(R)-1,2,2-trimethylpropyl]-4-methylbenzeneacetamide ,  (S)-α-Fluoro-α-cyano-N-[(S)-1-cyclohexylethyl]-4-methylbenzeneacetamide ,  (S)-α-Fluoro-α-cyano-N-[(1R)-2α-isopropylcyclohexane-1β-yl]-4-methylbenzeneacetamide ,  (S)-α-Fluoro-α-cyano-N-[(4α)-1β,7,7-trimethylbicyclo[2.2.1]heptane-2β-yl]-4-methylbenzeneacetamide ,  (S)-α-Fluoro-α-cyano-N-[(S)-α-methylbenzyl]-4-methylbenzeneacetamide ,  (S)-α-Fluoro-α-cyano-N-[(S)-1-(1-naphthyl)ethyl]-4-methylbenzeneacetamide ,  (S)-α-Fluoro-α-cyano-N-[(S)-α-methyl-4-nitrobenzyl]-4-methylbenzeneacetamide ,  (S)-α-Fluoro-α-cyano-N-[(S)-α,4-dimethylbenzyl]-4-methylbenzeneacetamide ,  N-[(S)-Fluorocyano(4-methylphenyl)acetyl]-L-alanine methyl ester ,  N-[(S)-Fluorocyano(4-methylphenyl)acetyl]-D-norvaline methyl ester ,  N-[(S)-Fluorocyano(4-methylphenyl)acetyl]-L-valine methyl ester ,  N-[(S)-Fluorocyano(4-methylphenyl)acetyl]-3-methyl-L-valine methyl ester ,  N-[(S)-Fluorocyano(4-methylphenyl)acetyl]-L-leucine methyl ester ,  N-[(S)-Fluorocyano(4-methylphenyl)acetyl]-L-methionine methyl ester ,  N-[(S)-Fluorocyano(4-methylphenyl)acetyl]-L-aspartic acid 1-methyl 4-benzyl ester ,  N-[(S)-Fluorocyano(4-methylphenyl)acetyl]-L-glutamic acid 1-methyl 5-ethyl ester ,  N-[(S)-Fluorocyano(4-methylphenyl)acetyl]-O-benzyl-L-threonine methyl ester ,  N-[(S)-Fluorocyano(4-methylphenyl)acetyl]-L-phenylalanine methyl ester ,  N^α-[(S)-Fluorocyano(4-methylphenyl)acetyl]-L-tryptophan methyl ester ,  (S)-3-[[(S)-Fluorocyano(4-methylphenyl)acetyl]amino]-5-methylhexanoic acid methyl ester

Terms in the title (7)： CFTA ,  1H-NMR ,  スペクトル ,  解析 ,  キラル ,  アミン類 ,  絶対配置