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J-GLOBAL ID：200902238447643390   Reference number：09A0130578

Preventing the unfolded protein response via aberrant activation of 4E-binding protein 1 by versipelostatin

4E結合蛋白質の異常な活性を介した蛋白質の折りたたみ不全応答のベルシペロスタチンによる阻害

Author (10)： MATSUO Junichi (Japanese Foundation for Cancer Res., Tokyo) ,  MATSUO Junichi (Univ. Tokyo, Tokyo, JPN) ,  TSUKUMO Yoshinori (Japanese Foundation for Cancer Res., Tokyo) ,  SAKURAI Junko (Japanese Foundation for Cancer Res., Tokyo) ,  TSUKAHARA Satomi (Japanese Foundation for Cancer Res., Tokyo) ,  PARK Hae-Ryong (Kyungnam Univ., Masan, KOR) ,  SHIN-YA Kazuo (National Inst. of Advanced Industrial Sci. and Technol., Tokyo, JPN) ,  WATANABE Toshiki (Univ. Tokyo, Tokyo, JPN) ,  TSURUO Takashi (Japanese Foundation for Cancer Res., Tokyo) ,  TOMIDA Akihiro (Japanese Foundation for Cancer Res., Tokyo)
Material： Cancer Science  (Cancer Sci)
Volume： 100  Issue： 2  Page： 327-333  Publication year： Feb. 2009 
JST Material Number： W1423A  ISSN： 1347-9032  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： in vivo experiment ,...

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JST classification (1)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (2)： Antitumor JL 68 ,  Sirolimus

Reference (35)：

• BROWN, JM. The unique physiology of solid tumors : opportunities (and problems) for cancer therapy. Cancer Res. 1998, 58, 1408-1416
• SCRIVAEN, P. The unfolded protein response and cancer : a brighter future unfolding?. J Mol Med. 2007, 85, 331-341
• ZHAO, L. Endoplasmic reticulum stress in health and disease. Curr Opin Cell Biol. 2006, 18, 1-9
• MA, Y. The role of the unfolded protein response in tumor development : friend or foe?. Nat Rev Cancer. 2004, 4, 966-977
• LEE, AS. GRP78 induction in cancer : therapeutic and prognostic implications. Cancer Res. 2007, 67, 3496-3499

Terms in the title (7)： 結合蛋白質 ,  活性 ,  蛋白質 ,  折りたたみ ,  応答 ,  ベルシペロスタチン ,  阻害