Art

J-GLOBAL ID：200902240637853220   Reference number：08A1107488

Identification of pharmacological inhibitors of the MEK5/ERK5 pathway

MER5/ERK5経路の薬理学的阻害剤の同定

Author (10)： TATAKE Revati J. (Dep. of Cardiovascular Disease, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877 ...) ,  O'NEILL Margaret M. (Dep. of Cardiovascular Disease, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877 ...) ,  KENNEDY Charles A. (Dep. of Cardiovascular Disease, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877 ...) ,  WAYNE Anita L. (Dep. of Cardiovascular Disease, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877 ...) ,  JAKES Scott (Dep. of Cardiovascular Disease, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877 ...) ,  WU Di (Dep. of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877, USA) ,  KUGLER Stanley Z. (Dep. of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877, USA) ,  KASHEM Mohammed A. (Dep. of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877, USA) ,  KAPLITA Paul (Dep. of Drug Discovery Support, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877 ...) ,  SNOW Roger J. (Dep. of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877, USA)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 377  Issue： 1  Page： 120-125  Publication year： Dec. 05, 2008 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： HeLa cell ,  HEK293 cell ,  *MAP kinase kinase ,  *enzyme inhibitor ,  ERK ,  DNA binding protein ,  transcription factor ,  phosphorylation ,  substrate (biochemistry) ,  transcription (genetics) ,  alditol ,  Erk1/2 ,  HEK293T cell ,  *MEK5 ,  *Signal Transduction ,  Mitogen-Activated Protein Kinase 7 ,  MEF2C protein
Semi thesaurus term： *cellular signal transduction ,  ERK5 ,  MEF2C

JST classification (2)： Enzyme in general  (EB09010D) ,  Cell physiology in general  (EF02010S)

Substance index (3)： Sorbitol ,  BIX-02188 ,  BIX-02189

Terms in the title (5)： ERK5 ,  経路 ,  薬理学 ,  阻害剤 ,  同定