Art

J-GLOBAL ID：200902240806621776   Reference number：07A1149842

N-hexacosanol prevents diabetes-induced rat ileal dysfunction without qualitative alteration of the muscarinic receptor system

N-ヘキサコサノールはムスカリン受容体系の質的変化を伴わない糖尿病誘発性ラット回腸の機能障害を防止する

Author (10)： NARIMATSU Naho (Dep. of Pathophysiological and Therapeutic Sci., Div. of Molecular Pharmacology, Tottori Univ. Fac. of Medicine) ,  SAITO Motoaki (Dep. of Pathophysiological and Therapeutic Sci., Div. of Molecular Pharmacology, Tottori Univ. Fac. of Medicine) ,  KAZUYAMA Emi (Dep. of Pathophysiological and Therapeutic Sci., Div. of Molecular Pharmacology, Tottori Univ. Fac. of Medicine) ,  HISADOME Yoshie (Dep. of Pathophysiological and Therapeutic Sci., Div. of Molecular Pharmacology, Tottori Univ. Fac. of Medicine) ,  KINOSHITA Yukako (Dep. of Pathophysiological and Therapeutic Sci., Div. of Molecular Pharmacology, Tottori Univ. Fac. of Medicine) ,  SATOH Itaru (Dep. of Pathophysiological and Therapeutic Sci., Div. of Molecular Pharmacology, Tottori Univ. Fac. of Medicine) ,  OKADA Shin-ichi (Dep. of Pathophysiological and Therapeutic Sci., Div. of Molecular Pharmacology, Tottori Univ. Fac. of Medicine) ,  SUZUKI Hiroto (Meiji Dairies Corp. Pharmaceuticals Dep.) ,  YAMADA Masashi (Meiji Dairies Corp. Pharmaceuticals Dep.) ,  SATOH Keisuke (Dep. of Pathophysiological and Therapeutic Sci., Div. of Molecular Pharmacology, Tottori Univ. Fac. of Medicine)
Material： Biomedical Research  (Biomed Res)
Volume： 28  Issue： 5  Page： 267-273 (J-STAGE)  Publication year： 2007 
JST Material Number： Z0236B  ISSN： 0388-6107  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： muscarinic receptor ,...
Semi thesaurus term： bridged compound ,...

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JST classification (3)： Basic research of drugs acting on digestive system  (GW09010Q) ,  Gene expression  (EC02040Q) ,  Intestines  (EJ06040N)

Substance index (7)： 1-Hexacosanol ,  tCFA-15 ,  4-DAMP ,  Atropine ,  Carbachol ,  Pirenzepine ,  Methoctramine

Reference (20)：

• 1. Arunlakshana O and Schild HO (1959) Some quantitative uses of drug antagonists. Br J Pharmacol Chemother 14, 48-58.
• 2. Brog J, Kesslak PJ and Cotman CW (1990) Peripheral administration of a long-chain fatty alcohol promotes septal cholinergic neurons survival after fimbria-fornix transection. Brain Res 518, 295-298.
• 3. Borg J, Toazara J, Heitter H, Henry M, Schmitt G and Luu B (1987) Neurotrophic effect of naturally occurring longchain fatty alcohols on cultured CNS neurons. FEBS lett 213, 406-410.
• 4. Carrier GO and Aronstam RS (1990) Increased muscarinic responsiveness and decreased muscarinic receptor content in ileal smooth muscle in diabetes. J Pharmacol Exp Ther 254, 445-449.
• 5. Caufield MP and Birdsall NJ (1998) International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev 50, 279-290.

Terms in the title (6)： ムスカリン受容体 ,  質的変化 ,  糖尿病 ,  ラット ,  回腸 ,  機能障害