Art

J-GLOBAL ID：200902240982488128   Reference number：06A0919748

Induction of Human P-Glycoprotein in Caco-2 cells: Development of a Highly Sensitive Assay System for P-Glycoprotein-Mediated Drug Transport

Caco-2細胞におけるヒトP-糖蛋白質の誘導:P-糖蛋白質仲介薬剤輸送の高感度分析系の開発

Author (10)： SHIRASAKA Yoshiyuki (Setsunan Univ., Osaka, JPN) ,  KAWASAKI Masae (Setsunan Univ., Osaka, JPN) ,  SAKANE Toshiyasu (Setsunan Univ., Osaka, JPN) ,  OMATSU Hideaki (Kobe Univ., Kobe, JPN) ,  MORIYA Yuka (Kobe Univ., Kobe, JPN) ,  NAKAMURA Tsutomu (Kobe Univ., Kobe, JPN) ,  SAKAEDA Toshiyuki (Kobe Univ., Kobe, JPN) ,  OKUMURA Katsuhiko (Kobe Univ., Kobe, JPN) ,  LANGGUTH Peter (Johannes Gutenberg-Univ., Mainz, DEU) ,  YAMASHITA Shinji (Setsunan Univ., Osaka, JPN)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 21  Issue： 5  Page： 414-423  Publication year： Oct. 30, 2006 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： bridged compound

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JST classification (1)： Basic biopharmacy  (GY01021U)

Substance index (1)： Vinblastine

Reference (38)：

• 1) Thiebaut, F., Tsuruo, T., Hamada, H., Gottesman, M. M., Pastan, I. and Willingham, M. C.: Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc. Natl. Acad. Sci. USA., 84: 7735-7738 (1987).
• 2) Hunter, J. and Hirst, B. H.: Intestinal secretion of drugs: The role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption. Adv. Drug Del. Rev., 25: 129-157 (1997).
• 3) Gao, J., Murase, O., Schowen, R. L., Aube, J. and Borchardt, R. T.: A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells. Pharm Res., 18: 171-176 (2001).
• 4) Meijer, D. K., Smit, J. W. and Muller, M.: Hepatobiliary elimination of cationic drugs: the role of P-glycoprotein and other ATP-dependent transporters. Adv. Drug Del. Rev., 25: 159-200 (1997).
• 5) Fromm, M. F.: P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs. Int. J. Clin. Pharmacol. Ther., 38: 69-74 (2000).

Terms in the title (9)： Caco-2細胞 ,  ヒト ,  P-糖蛋白質 ,  誘導 ,  仲介 ,  薬剤 ,  輸送 ,  感度分析 ,  開発