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J-GLOBAL ID：200902241179892609   Reference number：04A0498107

Mass Spectrometry on Hydrogen/Deuterium Exchange of Dihydrofolate Reductase: Effects of Ligand Binding

ジヒドロ葉酸レダクターゼの水素/重水素交換における質量分析:リガンド結合の影響

Author (3)： YAMAMOTO T (Hiroshima Univ., Higashi-Hiroshima) ,  IZUMI S (Hiroshima Univ., Higashi-Hiroshima) ,  GEKKO K (Hiroshima Univ., Higashi-Hiroshima)
Material： Journal of Biochemistry  (J Biochem)
Volume： 135  Issue： 6  Page： 663-671  Publication year： Jun. 01, 2004 
JST Material Number： F0286A  ISSN： 0021-924X  CODEN： JOBIAO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *dihydrofolate reductase ,...

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JST classification (2)： Enzyme in general  (EB09010D) ,  Microorganism biochemistry  (EG03020N)

Substance index (6)： Folic Acid ,  Dihydrofolic acid ,  Tetrahydrofolic acid ,  NADPH ,  NADP ,  Methotrexate

Reference (29)：

• SAWAYA, M. R. Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate-reductase : crystallographic evidence. Biochemistry. 1997, 36, 586-603
• LUMRY, R. The new paradigm for protein research. Protein-Solvent Interactions. 1995, 1-141
• BYSTROFF, C. Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding. Biochemistry. 1991, 30, 2227-2239
• KITAHARA, R. High pressure NMR reveals active-site hinge motion of folate-bound Escherichia coli dihydrofolate reductase. Biochemistry. 2000, 39, 12789-12795
• GEKKO, K. Point mutations at glycine-121 of Escherichia coli dihydrofolate reductase : important roles of a flexible loop in the stability and function. J. Biochem. 1994, 116, 34-41

Terms in the title (5)： ジヒドロ葉酸レダクターゼ ,  水素 ,  重水素 ,  質量分析 ,  リガンド結合