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J-GLOBAL ID：200902242697135400   Reference number：09A0306750

Achyranthoside H methyl ester, a novel oleanolic acid saponin derivative from Achyranthes fauriei roots, induces apoptosis in human breast cancer MCF-7 and MDA-MB-453 cells via a caspase activation pathway

Achyranthes faurieiの根由来の新規オレイン酸サポニンアキラントシドHメチルエステルは,カスパーゼ活性経路を介してヒト乳癌MCF-7およびMDA-MB-453細胞のアポトーシスを誘導する

Author (6)： FUKUMURA Motonori (Showa Univ., Tokyo, JPN) ,  ANDO Hidehiro (Showa Univ., Tokyo, JPN) ,  HIRAI Yasuaki (Showa Univ., Tokyo, JPN) ,  TORIIZUKA Kazuo (Showa Univ., Tokyo, JPN) ,  IDA Yoshiteru (Yokohama Coll. Pharmacy, Yokohama, JPN) ,  KUCHINO Yoshiyuki (Yokohama Coll. Pharmacy, Yokohama, JPN)
Material： Journal of Natural Medicines  (J Nat Med)
Volume： 63  Issue： 2  Page： 181-188  Publication year： 2009 
JST Material Number： L5856A  ISSN： 1340-3443  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *plant preparation ,...

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JST classification (1)： Basic research of pharmacology of crude drugs  (GX06020J)

Substance index (1)： Achyranthoside H methyl ester

Reference (26)：

• BACHRAN, C. Saponins in tumor therapy. Mini Rev Med Chem. 2008, 8, 575-584
• IDA, Y. Achyranthosides A and B, novel cytotoxic saponins from Achyranthes fauriei root. Tetrahedron Lett. 1994, 35, 6887-6890
• ANDO, H. Two new glucuronide saponins, Achyranthosides G and H, from Achyranthes fauriei root. J Nat Med. 2008, 62, 57-62
• KATO, H. Trends in Site-specific Crude Mortality Rate. Cancer Statistics in Japan-2007. 2007, 24
• BACUS, SS. Expression of the erbB-2 family of growth factor receptors and their ligands in breast cancers. Implication for tumor biology and clinical behavior. Am J Clin Pathol. 1994, 102, S13-S24

Terms in the title (11)： 根 ,  オレイン酸 ,  メチルエステル ,  カスパーゼ活性 ,  経路 ,  ヒト ,  乳癌 ,  MCF-7 ,  MDA-MB-453細胞 ,  アポトーシス ,  誘導