Art

J-GLOBAL ID：200902243060975614   Reference number：05A0522315

Substrate Specificity of Opioid Compounds to UDP-Glucuronosyltransferase (UGT), hUGT2B7 and Bovine Microsomal UGT

UDP-グルクロノシルトランスフェラーゼ(UGT),hUGT2B7及びウシのミクロソームUGTに対するオピオイド化合物の基質特異性

Author (4)： IWAMURA Tatsunori (Dep. of Organic Chemistry, Gifu Pharmaceutical Univ.) ,  ITO Yuko (Dep. of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City Univ.) ,  KUNO Nayumi (Dep. of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City Univ.) ,  MIZUTANI Takaharu (Dep. of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City Univ.)
Material： Journal of Health Science  (J Health Sci)
Volume： 51  Issue： 3  Page： 325-332 (J-STAGE)  Publication year： 2005 
JST Material Number： S0030A  ISSN： 1344-9702  CODEN： JHSCFD  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *opioid peptide ,...
Semi thesaurus term： glucuronosyltransferase

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JST classification (1)： Biological function  (EB03040U)

Reference (39)：

• 1) Evans, W. E. and Relling, M. V. (1999) Pharmacogenomics: Transalating functional genomics into rational therapeutics. Science, 286, 487-491.
• 2) King, C., Finley, B. and Franklin, R. (2000) The glucuronidation of morphine by dog liver microsome; identifiaction of morphine-6-O-glucoronide. Drug Metab. Dispos., 28, 661-663.
• 3) Radominska-Pandya, A., Czernik, P. J., Little, J. M., Battaglia, E. and Mackenzie, P. I. (1999) Structural and Functional studies of UDP-glucuronyltransferases. Drug Metab. Rev., 31, 817-899.
• 4) Fisher, M. B., Paine, M. F., Strelevitz, T. J. and Wrighton, S. A. (2001) The role of hepatic and extrahepatic UDP-glucoronosyltransferase in human drug metabolism. Drug Metab. Rev., 33, 273-297.
• 5) Vanstapel, F. and Blanckaert, N. (1988) Topology and regulation of bilirubin UDP-glucuronosyltransferase in sealed native microsomes from rat liver. Arch. Biochem. Biophys., 263, 216-225.

Terms in the title (6)： UDP ,  グルクロノシルトランスフェラーゼ ,  ウシ ,  ミクロソーム ,  オピオイド ,  基質特異性